In vivo real-time visualization of tissue blood flow and angiogenesis using Ag2S quantum dots in the NIR-II window

CORC > 苏州纳米技术与纳米仿生研究所 > 中国科学院苏州纳米技术与纳米仿生研究所 > 纳米生物医学与安全研究部 > 王强斌团队

	In vivo real-time visualization of tissue blood flow and angiogenesis using Ag2S quantum dots in the NIR-II window
	Wang, QB (王强斌); Wu, DM
刊名	BIOMATERIALS
	2014-01
卷号	35 期号:1 页码:393-400
关键词	Ag2S Quantum dots In vivo imaging Fluorescence Second near-infrared window
通讯作者	Wang, QB (王强斌)
英文摘要	Improving the tissue penetration depth and spatial resolution of fluorescence-based optical nanoprobes remains a grand challenge for their practical applications in in vivo imaging, due to the scattering and absorption and endogenous autofluorescence of living tissues. Here, we present that Ag2S quantum dots (QDs), containing no toxic ions, exhibiting long circulation time and high stability, act as a new kind of fluorescent probes in the second near-infrared window (NIR-II, 1000-1350 nm) which enable in vivo monitoring of lymphatic drainage and vascular networks with deep tissue penetration and high spatial and temporal resolution. In addition, NIR-II fluorescence imaging with Ag2S QDs provide ultrahigh spatial resolution (similar to 40 mu m) that permits us to track angiogenesis mediated by a tiny tumor (2-3 mm in diameter) in vivo. Our results indicate that Ag2S QDs are promising NIR-II fluorescent nanoprobes that could be useful in surgical treatments such as sentinel lymph node (SLN) dissection as well in assessment of blood supply in tissues and organs and screening of anti-angiogenic drugs.
收录类别	SCI
语种	英语
WOS记录号	WOS:000328006100039
公开日期	2014-12-01
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/1601]
专题	苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_王强斌团队
通讯作者	Wang, QB (王强斌)
推荐引用方式 GB/T 7714	Wang, QB ,Wu, DM. In vivo real-time visualization of tissue blood flow and angiogenesis using Ag2S quantum dots in the NIR-II window[J]. BIOMATERIALS,2014,35(1):393-400.
APA	Wang, QB ,&Wu, DM.(2014).In vivo real-time visualization of tissue blood flow and angiogenesis using Ag2S quantum dots in the NIR-II window.BIOMATERIALS,35(1),393-400.
MLA	Wang, QB ,et al."In vivo real-time visualization of tissue blood flow and angiogenesis using Ag2S quantum dots in the NIR-II window".BIOMATERIALS 35.1(2014):393-400.