Antheraea Pernyi Silk Fibroin Nanoparticles for Drug Delivery

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	Antheraea Pernyi Silk Fibroin Nanoparticles for Drug Delivery
	Jin, J (靳健)
刊名	JOURNAL OF NANO RESEARCH
	2014
卷号	27 期号:0 页码:75-81
关键词	fibroin nanoparticles drug delivery Antheraea pernyi Doxorubicin hydrochloride
通讯作者	Jin, J (靳健)
英文摘要	Silk nanoparticles were easily obtained from regenerated Antheraea Pernyi Silk Fibroin (ASF). The morphology and average size of the silk particles was sensitive to pH value of fibroin solution. The diameter of nanoparticles prepared was in the range of 30 nm to 1000 nm with a narrow size distribution. On this process, the molecular conformation of regenerated ASP changed from a-helix to beta-sheet structure. The shape of prepared nanoparticles were regular spherical structure when the pH value was about 4.3 (pI) in ASF solution. Doxorubicin hydrochloride (DOX) was loaded in the ASP particles as drug release model and the drug-loading ratio was 3.4 %. The release rate of DOX from ASF nanoparticles was pH sensitive. After 23 days release, there was still 84% DOX in the ASP nanoparticles. The result suggested that the ASF nanoparticles might be suitable microcarriers for drug delivery.
收录类别	SCI
语种	英语
WOS记录号	WOS:000339303600009
公开日期	2015-02-03
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/1738]
专题	苏州纳米技术与纳米仿生研究所_纳米仿生研究部_靳健团队
通讯作者	Jin, J (靳健)
推荐引用方式 GB/T 7714	Jin, J . Antheraea Pernyi Silk Fibroin Nanoparticles for Drug Delivery[J]. JOURNAL OF NANO RESEARCH,2014,27(0):75-81.
APA	Jin, J .(2014).Antheraea Pernyi Silk Fibroin Nanoparticles for Drug Delivery.JOURNAL OF NANO RESEARCH,27(0),75-81.
MLA	Jin, J ."Antheraea Pernyi Silk Fibroin Nanoparticles for Drug Delivery".JOURNAL OF NANO RESEARCH 27.0(2014):75-81.