Pharmaceutical Cocrystals of Diflunisal with Nicotinamide or Isonicotinamide | |
Wang, LY(汪莲艳)![]() ![]() ![]() | |
刊名 | ORGANIC PROCESS RESEARCH & DEVELOPMENT
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2013-11 | |
卷号 | 17期号:11页码:1413-1418 |
通讯作者 | Zhang, HL(张海禄) |
英文摘要 | In order to improve the solubility of diflunisal (DIF), and hence the oral bioavailability, two 2:1 diflunisal cocrystals were prepared by solution crystallization from ethanol with nicotinamide (NIC) or isonicotinamide (ISO) as coformer. The cocrystals were characterized by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), as well as liquid- and solid-state nuclear magnetic resonance (LNMR and SSNMR). PXRD and NMR measurements indicate that the pure 2:1 cocrystals can be obtained even the DIF and coformer started from different ratios (2:1, 1:1 and 1:2). FTIR and C-13 SSNMR measurements provide clues about the formation of amide-carboxylic acid heterosynthon and pyridine-carboxylic acid heterosynthon between DIF and coformer. The melting points of DIF-NIC and DIF-ISO cocrystals are 195 and 182 degrees C respectively, indicating their favorable thermal stability. Meanwhile, the two cocrystals exhibit faster dissolution rates and higher aqueous solubilities than the pure drug compound. |
收录类别 | SCI ; EI |
语种 | 英语 |
WOS记录号 | WOS:000327174900004 |
公开日期 | 2014-01-20 |
内容类型 | 期刊论文 |
源URL | [http://ir.sinano.ac.cn/handle/332007/1520] ![]() |
专题 | 苏州纳米技术与纳米仿生研究所_纳米仿生研究部_邓宗武团队 |
通讯作者 | Zhang, HL(张海禄) |
推荐引用方式 GB/T 7714 | Wang, LY,Deng, ZW,Zhang, HL. Pharmaceutical Cocrystals of Diflunisal with Nicotinamide or Isonicotinamide[J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT,2013,17(11):1413-1418. |
APA | Wang, LY,Deng, ZW,&Zhang, HL.(2013).Pharmaceutical Cocrystals of Diflunisal with Nicotinamide or Isonicotinamide.ORGANIC PROCESS RESEARCH & DEVELOPMENT,17(11),1413-1418. |
MLA | Wang, LY,et al."Pharmaceutical Cocrystals of Diflunisal with Nicotinamide or Isonicotinamide".ORGANIC PROCESS RESEARCH & DEVELOPMENT 17.11(2013):1413-1418. |
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