Pharmaceutical Cocrystals of Diflunisal with Nicotinamide or Isonicotinamide

CORC > 苏州纳米技术与纳米仿生研究所 > 中国科学院苏州纳米技术与纳米仿生研究所 > 纳米仿生研究部 > 邓宗武团队

	Pharmaceutical Cocrystals of Diflunisal with Nicotinamide or Isonicotinamide
	Wang, LY(汪莲艳); Deng, ZW(邓宗武); Zhang, HL(张海禄)
刊名	ORGANIC PROCESS RESEARCH & DEVELOPMENT
	2013-11
卷号	17 期号:11 页码:1413-1418
通讯作者	Zhang, HL(张海禄)
英文摘要	In order to improve the solubility of diflunisal (DIF), and hence the oral bioavailability, two 2:1 diflunisal cocrystals were prepared by solution crystallization from ethanol with nicotinamide (NIC) or isonicotinamide (ISO) as coformer. The cocrystals were characterized by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), as well as liquid- and solid-state nuclear magnetic resonance (LNMR and SSNMR). PXRD and NMR measurements indicate that the pure 2:1 cocrystals can be obtained even the DIF and coformer started from different ratios (2:1, 1:1 and 1:2). FTIR and C-13 SSNMR measurements provide clues about the formation of amide-carboxylic acid heterosynthon and pyridine-carboxylic acid heterosynthon between DIF and coformer. The melting points of DIF-NIC and DIF-ISO cocrystals are 195 and 182 degrees C respectively, indicating their favorable thermal stability. Meanwhile, the two cocrystals exhibit faster dissolution rates and higher aqueous solubilities than the pure drug compound.
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000327174900004
公开日期	2014-01-20
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/1520]
专题	苏州纳米技术与纳米仿生研究所_纳米仿生研究部_邓宗武团队
通讯作者	Zhang, HL(张海禄)
推荐引用方式 GB/T 7714	Wang, LY,Deng, ZW,Zhang, HL. Pharmaceutical Cocrystals of Diflunisal with Nicotinamide or Isonicotinamide[J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT,2013,17(11):1413-1418.
APA	Wang, LY,Deng, ZW,&Zhang, HL.(2013).Pharmaceutical Cocrystals of Diflunisal with Nicotinamide or Isonicotinamide.ORGANIC PROCESS RESEARCH & DEVELOPMENT,17(11),1413-1418.
MLA	Wang, LY,et al."Pharmaceutical Cocrystals of Diflunisal with Nicotinamide or Isonicotinamide".ORGANIC PROCESS RESEARCH & DEVELOPMENT 17.11(2013):1413-1418.