Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice

	Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice
	Wang B(汪冰); Feng WY(丰伟悦); Wang M(王萌); Zhu MT(朱墨桃); Ou YH(欧阳宏); Shi JW(史俊稳); Zhao YL(赵宇亮); Chai ZF(柴之芳); Wang, B; Feng, WY
刊名	JOURNAL OF NANOPARTICLE RESEARCH
	2008
卷号	10 期号:2 页码:#REF!
关键词	acute oral toxicity nano-meter zinc oxide powder submicro-meter zinc oxide powder mice toxicology health effects medicine
通讯作者	Feng, WY (reprint author), Chinese Acad Sci, Lab Bioenvironm Hlth Sci Nanoscale Mat & Nanosafe, Beijing 100049, Peoples R China.
英文摘要	In this work, the acute oral toxicity of 20- and 120-nm ZnO powder at doses of 1-, 2-, 3-, 4-, 5-g/kg body weight was evaluated referred to the OECD guidelines for testing of chemicals. As the results, both 20- and 120-nm ZnO belong to non-toxic chemicals according to the Globally Harmonized Classification System (GHS) for the classification of chemicals. The distribution determination showed that Zn was mainly retained in the bone, kidney and pancreas after 20- and 120-nm ZnO administration. However, the results of blood measurement suggest that the increase in blood viscosity could be induced by low and median dose of 20-nm ZnO but high dose of 120-nm ZnO. The pathological examination showed that the 120-nm ZnO treated mice had dose-effect pathological damages in stomach, liver, heart and spleen, whereas, 20-nm ZnO displayed negative dose-effect damages in liver, spleen and pancreas. Therefore, we conclude that the liver, spleen, heart, pancreas and bone are the target organs for 20- and 120-nm ZnO oral exposure. More attention should be paid on the potential toxicity induced by low dose of 20-nm ZnO oral exposure.
学科主题	Chemistry; Science & Technology - Other Topics; Materials Science
类目[WOS]	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
收录类别	SCI
WOS记录号	WOS:000251730400003
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/227271]
专题	高能物理研究所_院士高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Wang B,Feng WY,Wang M,et al. Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice[J]. JOURNAL OF NANOPARTICLE RESEARCH,2008,10(2):#REF!.
APA	汪冰.,丰伟悦.,王萌.,朱墨桃.,欧阳宏.,...&Wang, J.(2008).Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice.JOURNAL OF NANOPARTICLE RESEARCH,10(2),#REF!.
MLA	汪冰,et al."Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice".JOURNAL OF NANOPARTICLE RESEARCH 10.2(2008):#REF!.