Ytterbium and trace element distribution in brain and organic tissues of offspring rats after prenatal and postnatal exposure to ytterbium

	Ytterbium and trace element distribution in brain and organic tissues of offspring rats after prenatal and postnatal exposure to ytterbium
	Feng LX(冯流星); He X(何潇); Xiao HQ(肖海清); Li ZJ(李子杰); Li FL(李福亮); Liu NQ(刘年庆); Chai ZF(柴之芳); Zhao YL(赵宇亮); Zhang ZY(张智勇); Feng, LX
刊名	BIOLOGICAL TRACE ELEMENT RESEARCH
	2007
卷号	117 期号:1-3 页码:#REF!
关键词	ytterbium toxicology trace elements
通讯作者	Zhang, ZY (reprint author), Chinese Acad Sci, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China.
英文摘要	Lanthanides, because of their diversified physical and chemical effects, have been widely used in a number of fields. As a result, more and more lanthanides are entering the environment and eventually accumulating in the human body. Previous studies indicate that the impact of lanthanides on brain function cannot be neglected. Although neurological studies of trace elements are of paramount importance, up to now, little data are provided regarding the status of micronutritional elements in rats after prenatal and long-term exposure to lanthanide. The aim of this study is to determine the ytterbium (Yb) and trace elements distribution in brain and organic tissues of offspring rats after prenatal and long-term exposure to Yb. Wistar rats were exposed to Yb through oral administration at 0, 0.1, 2, and 40 mg Yb/kg concentrations from gestation day 0 through 5 mo of age. Concentrations of Yb and other elements (Mg, Ca, Fe, Cu, Mn, and Zn) in the serum, liver, femur, and brain regions (cerebral cortex, hippocampus, cerebellum, and the rest) of offspring rats at the age of 0 d, 25 d, and 5 mo were analyzed by inductively coupled plasma-mass spectrometry. The accumulation of Yb in the brain, liver, and femur is observed; moreover, the levels of Fe, Cu, Mn, Zn, Ca, and Mg in the brain and organic tissues of offspring rats are also altered after Yb exposure. This disturbance of the homeostasis of trace elements might induce adverse effects on normal physiological functions of the brain and other organs.
学科主题	Biochemistry & Molecular Biology; Endocrinology & Metabolism
类目[WOS]	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
收录类别	SCI
WOS记录号	WOS:000248847400009
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/226067]
专题	高能物理研究所_院士高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Feng LX,He X,Xiao HQ,et al. Ytterbium and trace element distribution in brain and organic tissues of offspring rats after prenatal and postnatal exposure to ytterbium[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2007,117(1-3):#REF!.
APA	冯流星.,何潇.,肖海清.,李子杰.,李福亮.,...&Zhang, ZY.(2007).Ytterbium and trace element distribution in brain and organic tissues of offspring rats after prenatal and postnatal exposure to ytterbium.BIOLOGICAL TRACE ELEMENT RESEARCH,117(1-3),#REF!.
MLA	冯流星,et al."Ytterbium and trace element distribution in brain and organic tissues of offspring rats after prenatal and postnatal exposure to ytterbium".BIOLOGICAL TRACE ELEMENT RESEARCH 117.1-3(2007):#REF!.