A generalized method of converting CT image to PET linear attenuation coefficient distribution in PET/CT imaging

CORC > 高能物理研究所 > 中国科学院高能物理研究所 > 核技术应用研究中心

	A generalized method of converting CT image to PET linear attenuation coefficient distribution in PET/CT imaging
	Wang L(王璐); Wu LW(武丽伟); Wei L(魏乐); Wang, L; Wu, LW; Wei, L; Gao, J; Sun, CL; Chai, P; Li, DW
刊名	CHINESE PHYSICS B
	2014
卷号	23 期号:2 页码:27802
关键词	linear attenuation coefficient PET/CT attenuation correction consistency conditions
英文摘要	The accuracy of attenuation correction in positron emission tomography scanners depends mainly on deriving the reliable 511-keV linear attenuation coefficient distribution in the scanned objects. In the PET/CT system, the linear attenuation distribution is usually obtained from the intensities of the CT image. However, the intensities of the CT image relate to the attenuation of photons in an energy range of 40 keV-140 keV. Before implementing PET attenuation correction, the intensities of CT images must be transformed into the PET 511-keV linear attenuation coefficients. However, the CT scan parameters can affect the effective energy of CT X-ray photons and thus affect the intensities of the CT image. Therefore, for PET/CT attenuation correction, it is crucial to determine the conversion curve with a given set of CT scan parameters and convert the CT image into a PET linear attenuation coefficient distribution. A generalized method is proposed for converting a CT image into a PET linear attenuation coefficient distribution. Instead of some parameter-dependent phantom calibration experiments, the conversion curve is calculated directly by employing the consistency conditions to yield the most consistent attenuation map with the measured PET data. The method is evaluated with phantom experiments and small animal experiments. In phantom studies, the estimated conversion curve fits the true attenuation coefficients accurately, and accurate PET attenuation maps are obtained by the estimated conversion curves and provide nearly the same correction results as the true attenuation map. In small animal studies, a more complicated attenuation distribution of the mouse is obtained successfully to remove the attenuation artifact and improve the PET image contrast efficiently.
学科主题	Physics
收录类别	SCI
WOS记录号	WOS:000332104800087
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/224897]
专题	高能物理研究所_核技术应用研究中心
推荐引用方式 GB/T 7714	Wang L,Wu LW,Wei L,et al. A generalized method of converting CT image to PET linear attenuation coefficient distribution in PET/CT imaging[J]. CHINESE PHYSICS B,2014,23(2):27802.
APA	王璐.,武丽伟.,魏乐.,Wang, L.,Wu, LW.,...&李道武.(2014).A generalized method of converting CT image to PET linear attenuation coefficient distribution in PET/CT imaging.CHINESE PHYSICS B,23(2),27802.
MLA	王璐,et al."A generalized method of converting CT image to PET linear attenuation coefficient distribution in PET/CT imaging".CHINESE PHYSICS B 23.2(2014):27802.