Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging

	Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging
	Cao, MJ; Wang, PY; Kou, Y; Wang, J; Liu, J; Li, YH; Li, JY; Wang, LM; Chen, CY; Wang LM(王黎明)
刊名	ACS APPLIED MATERIALS & INTERFACES
	2015
卷号	7 期号:45 页码:25014-25023
关键词	photothermal therapy magnetic resonance imaging chemotherapy multimodal therapy drug delivery mesoporous silica nanoparticles gadolinium(III)-chelated silica nanospheres
英文摘要	The combination of therapy and diagnosis has been emerging as a promising strategy for cancer treatment. To realize chemotherapy, photothermal therapy, and magnetic resonance imaging (MRI) in one system, we have synthesized a new magnetic nanoparticle (Gd@SiO2-DOX/ICG-PDC) integrating doxorubicin (DOX), indocyanine green (ICG), and gadolinium(III)-chelated silica nanospheres (Gd@SiO2) with a poly(diallyldimethylammonium chloride) (PDC) coating. PDC coating serves as a polymer layer to protect from quick release of drugs from the nanocarriers and increase cellular uptake. The DOX release from Gd@SiO2-DOX/ICG-PDC depends on pH and temperature. The process will be accelerated in the acidic condition than in a neutral pH 7.4. Meanwhile, upon laser irradiation, the photothermal effects promote DOX release and improve the therapeutic efficacy compared to either DOX-loaded Gd@SiO2 or ICG-loaded Gd@SiO2. Moreover, MRI results show that the Gd@SiO2-PDC nanoparticles are safe T-1-type MRI contrast agents for imaging. The Gd@SiO2-PDC nanoparticles loaded with DOX and ICG can thus act as a promising theranostic platform for multimodal cancer treatment.
学科主题	Science & Technology - Other Topics; Materials Science
类目[WOS]	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
收录类别	SCI ; EI ; CA
WOS记录号	WOS:000365148600007
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/228806]
专题	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Cao, MJ,Wang, PY,Kou, Y,et al. Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(45):25014-25023.
APA	Cao, MJ.,Wang, PY.,Kou, Y.,Wang, J.,Liu, J.,...&王黎明.(2015).Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging.ACS APPLIED MATERIALS & INTERFACES,7(45),25014-25023.
MLA	Cao, MJ,et al."Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging".ACS APPLIED MATERIALS & INTERFACES 7.45(2015):25014-25023.