A novel form of beta-strand assembly observed in A beta(33-42) adsorbed onto graphene

	A novel form of beta-strand assembly observed in A beta(33-42) adsorbed onto graphene
	Wang XF(王晓峰); Wang, XF; Weber, JK; Liu, L; Dong, MD; Zhou, RH; Li, JY; Li JY(李敬源)
刊名	NANOSCALE
	2015
卷号	7 期号:37 页码:15341-15348
通讯作者	李敬源
英文摘要	Peptide assembly plays a seminal role in the fabrication of structural and functional architectures in cells. Characteristically, peptide assemblies are often dominated by beta-sheet structures, wherein component molecules are connected by backbone hydrogen bonds in a parallel or an antiparallel fashion. While beta-rich peptide scaffolds are implicated in an array of neurodegenerative diseases, the mechanisms by which toxic peptides assemble and mediate neuropathic effects are still poorly understood. In this work, we employ molecular dynamics simulations to study the adsorption and assembly of the fragment A beta(33-42) (taken from the A beta-42 peptide widely associated with Alzheimer's disease) on a graphene surface. We observe that such A beta(33-42) fragments, which are largely hydrophobic in character, readily adsorb onto the graphitic surface and coalesce into a well-structured, beta-strand-like assembly. Strikingly, the structure of such complex is quite unique: hydrophobic side-chains extend over the graphene surface and interact with adjacent peptides, yielding a well-defined mosaic of hydrophobic interaction patches. This ordered structure is markedly depleted of backbone hydrogen bonds. Hence, our simulation results reveal a distinct type of beta-strand assembly, maintained by hydrophobic side-chain interactions. Our finding suggests the backbone hydrogen bond is no longer crucial to the peptide assembly. Further studies concerning whether such beta-strand assembly can be realized in other peptide systems and in biologically-relevant contexts are certainly warranted.
学科主题	Chemistry; Science & Technology - Other Topics; Materials Science; Physics
类目[WOS]	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
收录类别	SCI ; EI ; CA ; MEDLINE
WOS记录号	WOS:000361675300042
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/228721]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Wang XF,Wang, XF,Weber, JK,et al. A novel form of beta-strand assembly observed in A beta(33-42) adsorbed onto graphene[J]. NANOSCALE,2015,7(37):15341-15348.
APA	王晓峰.,Wang, XF.,Weber, JK.,Liu, L.,Dong, MD.,...&李敬源.(2015).A novel form of beta-strand assembly observed in A beta(33-42) adsorbed onto graphene.NANOSCALE,7(37),15341-15348.
MLA	王晓峰,et al."A novel form of beta-strand assembly observed in A beta(33-42) adsorbed onto graphene".NANOSCALE 7.37(2015):15341-15348.