Silica-coated bismuth sulfide nanorods as multimodal contrast agents for a non-invasive visualization of the gastrointestinal tract

	Silica-coated bismuth sulfide nanorods as multimodal contrast agents for a non-invasive visualization of the gastrointestinal tract
	Zheng XP(郑晓鹏); Shi JX(施俊新); Tian G(田甘); Zhang X(张潇); Yin WY(尹文艳); Yan L(晏亮); Gu ZJ(谷战军); Zhao YL(赵宇亮); Zheng, XP; Shi, JX
刊名	NANOSCALE
	2015
卷号	7 期号:29 页码:12581-12591
通讯作者	晏亮 ; 谷战军 ; 赵宇亮
英文摘要	Non-invasive and real-time imaging of the gastrointestinal (GI) tract is particularly desirable for research and clinical studies of patients with symptoms arising from gastrointestinal diseases. Here, we designed and fabricated silica-coated bismuth sulfide nanorods (Bi2S3@SiO2 NRs) for a non-invasive spatial-temporally imaging of the GI tract. The Bi2S3 NRs were synthesized by a facile solvothermal method and then coated with a SiO2 layer to improve their biocompatibility and stability in the harsh environments of the GI tract, such as the stomach and the small intestine. Due to their strong X-ray- and near infrared-absorption abilities, we demonstrate that, following oral administration in mice, the Bi2S3@SiO2 NRs can be used as a dual-modal contrast agent for the real-time and non-invasive visualization of NRs distribution and the GI tract via both X-ray computed tomography (CT) and photoacoustic tomography (PAT) techniques. Importantly, integration of PAT with CT provides complementary information on anatomical details with high spatial resolution. In addition, we use Caenorhabditis Elegans (C. Elegans) as a simple model organism to investigate the biological response of Bi2S3@SiO2 NRs by oral administration. The results indicate that these NRs can pass through the GI tract of C. Elegans without inducing notable toxicological effects. The above results suggest that Bi2S3@SiO2 NRs pave an alternative way for the fabrication of multi-modal contrast agents which integrate CT and PAT modalities for a direct and non-invasive visualization of the GI tract with low toxicity.
学科主题	Chemistry; Science & Technology - Other Topics; Materials Science; Physics
类目[WOS]	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
收录类别	SCI ; EI ; CA ; MEDLINE
WOS记录号	WOS:000358207700041
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/228587]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Zheng XP,Shi JX,Tian G,et al. Silica-coated bismuth sulfide nanorods as multimodal contrast agents for a non-invasive visualization of the gastrointestinal tract[J]. NANOSCALE,2015,7(29):12581-12591.
APA	郑晓鹏.,施俊新.,田甘.,张潇.,尹文艳.,...&Zhao, YL.(2015).Silica-coated bismuth sulfide nanorods as multimodal contrast agents for a non-invasive visualization of the gastrointestinal tract.NANOSCALE,7(29),12581-12591.
MLA	郑晓鹏,et al."Silica-coated bismuth sulfide nanorods as multimodal contrast agents for a non-invasive visualization of the gastrointestinal tract".NANOSCALE 7.29(2015):12581-12591.