Evaluation of anti-osteoporosis in ovariectomized Wistar rats treated with antler blood by synchrotron radiation X-ray fluorescence microprobe

	Evaluation of anti-osteoporosis in ovariectomized Wistar rats treated with antler blood by synchrotron radiation X-ray fluorescence microprobe
	Yang, JH; Wang, RL; Cao, Y; Fei, YR; Huang, YY; He, W; Liu, J; Huang YY(黄宇营); He W(何伟)
刊名	SPECTROSCOPY-AN INTERNATIONAL JOURNAL
	2009
卷号	23 期号:1 页码:1-9
关键词	Element analysis BMD osteoporosis femur SRXRF
通讯作者	Yang, JH (reprint author), Chinese Acad Sci, Grad Univ, Sch Life Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China.
英文摘要	To evaluate the anti-osteoporotic effect of antler blood, the relationship between the change of element content and the bone mineral density (BMD) increase in femur was investigated. Female Wistar rats were randomly divided into three groups: sham-operated group (SHAM, n = 5), ovariectomized group (OVX, n = 5) and ovariectomized group with antler blood treatment (n = 5). The femoral BMD was analyzed by dual-energy X-ray absorptiometry (DXA) and the element relative content was determined by synchrotron radiation X-ray fluorescence (SRXRF) microprobe. The results showed that the femoral BMD in ovariectomized rats was significantly lower than that of sham-operated rats (p < 0.05) but reversed by antler blood treatment (p < 0.05). A further study demonstrated that the relative contents of phosphorus (P), calcium (Ca), zinc (Zn) and strontium (Sr) were obviously lower in ovariectomized rats compared to sham-operated rats but only the relative contents of P, Ca and Zn were normalized by antler blood treatment (p < 0.05). Our experiments revealed that loss of element Ca, P, Zn and Sr was closely related to the BMD reduction in ovariectomized rats and the anti-osteoporotic effect of antler blood was mediated by increasing the contents of P, Ca and Zn.
学科主题	Biochemistry & Molecular Biology; Spectroscopy
类目[WOS]	Biochemical Research Methods ; Spectroscopy
收录类别	SCI
WOS记录号	WOS:000265564100001
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/225415]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Yang, JH,Wang, RL,Cao, Y,et al. Evaluation of anti-osteoporosis in ovariectomized Wistar rats treated with antler blood by synchrotron radiation X-ray fluorescence microprobe[J]. SPECTROSCOPY-AN INTERNATIONAL JOURNAL,2009,23(1):1-9.
APA	Yang, JH.,Wang, RL.,Cao, Y.,Fei, YR.,Huang, YY.,...&何伟.(2009).Evaluation of anti-osteoporosis in ovariectomized Wistar rats treated with antler blood by synchrotron radiation X-ray fluorescence microprobe.SPECTROSCOPY-AN INTERNATIONAL JOURNAL,23(1),1-9.
MLA	Yang, JH,et al."Evaluation of anti-osteoporosis in ovariectomized Wistar rats treated with antler blood by synchrotron radiation X-ray fluorescence microprobe".SPECTROSCOPY-AN INTERNATIONAL JOURNAL 23.1(2009):1-9.