Er3+-doped YbPO4 up-conversion porous nanospheres for UCL/CT bimodal imaging in vivo and chemotherapy | |
Zheng XP(郑晓鹏); Zhou LJ(周亮君); Yin WY(尹文艳); Zheng, XP; Zhou, LJ; Bu, Y; Yin, WY; Hu, ZB; Li, M; Gu, ZJ | |
刊名 | JOURNAL OF MATERIALS CHEMISTRY B |
2014 | |
卷号 | 2期号:38页码:6508-6516 |
英文摘要 | The combined use nanotechnology and medical technologies holds great promise for the development and improvement of various theranostic media. Here, based on a facile hydrothermal method, polyethyleneimine (PEI) functionalized YbPO4: Er up-conversion porous nanospheres (UCPSs) were fabricated, which combined the capabilities of up-conversion luminescence (UCL)/X-ray computed tomography (CT) bimodal imaging and drug delivery. The resulting hydrophilic PEI functionalized YbPO4: Er UCPSs (PEI-UCPSs) showed uniform morphology and high crystallinity. Moreover, PEI-UCPSs possessed high drug loading capacity because of their large specific surface area, which was confirmed by the Brunauer-Emmett-Teller (BET) experiment. Cellular experiments indicated that the PEI-UCPSs had low cytotoxicity and confirmed the performance of the pH-mediated cancer targeting of PEI-UCPSs@DOX. Importantly, because of the ideal UCL property and high CT contrast both in vitro and in vivo, YbPO4: Er PEI-UCPSs could be used as an optical probe and a contrast agent for optical and CT imaging, forming a promising platform for simultaneous bioimaging and drug delivery. |
学科主题 | Materials Science |
收录类别 | SCI |
WOS记录号 | WOS:000342079900008 |
公开日期 | 2016-05-03 |
内容类型 | 期刊论文 |
源URL | [http://ir.ihep.ac.cn/handle/311005/225113] |
专题 | 高能物理研究所_多学科研究中心 |
推荐引用方式 GB/T 7714 | Zheng XP,Zhou LJ,Yin WY,et al. Er3+-doped YbPO4 up-conversion porous nanospheres for UCL/CT bimodal imaging in vivo and chemotherapy[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(38):6508-6516. |
APA | 郑晓鹏.,周亮君.,尹文艳.,Zheng, XP.,Zhou, LJ.,...&赵宇亮.(2014).Er3+-doped YbPO4 up-conversion porous nanospheres for UCL/CT bimodal imaging in vivo and chemotherapy.JOURNAL OF MATERIALS CHEMISTRY B,2(38),6508-6516. |
MLA | 郑晓鹏,et al."Er3+-doped YbPO4 up-conversion porous nanospheres for UCL/CT bimodal imaging in vivo and chemotherapy".JOURNAL OF MATERIALS CHEMISTRY B 2.38(2014):6508-6516. |
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