Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles

	Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles
	Gao FP(高福平); Yuan Q(袁卿); Gao J(高靓); Gao, FP; Yuan, Q; Gao, L; Cai, PJ; Zhu, HR; Liu, R; Wang, YL
刊名	BIOMATERIALS
	2014
卷号	35 期号:31 页码:8854-8866
关键词	Selenium nanoparticle Toxicity Antitumor drug Apoptosis Nrf2-ARE pathway
英文摘要	Although chemotherapeutic drugs are widely applied for clinic tumor treatment, severe toxicity restricts their therapeutic efficacy. In this study, we reported a new form of selenium, selenium nanoparticles (Nano Se) which have significant lower toxicity and acceptable bioavailability. We investigated Nano Se as chemotherapy preventive agent to protect against toxicities of anticancer drug irinotecan and synergistically enhance the anti-tumor treatment effect in vitro and in vivo. The underlying mechanisms were also investigated. The combination of Nano Se and irinotecan showed increased cytotoxic effect with HCT-8 tumor cells likely by p53 mediated apoptosis. Nano Se inhibited growth of HCT-8 tumor cells partially through caspases mediated apoptosis. In vivo experiment showed Nano Se at a dose of 4 mg/kg/day significantly alleviated adverse effects induced by irinotecan (60 mg/kg) treatment. Nano Se alone treatment did not induce any toxic manifestations. The combination of Nano Se and irinotecan dramatically inhibited tumor growth and significantly induced apoptosis of tumor cells in HCT-8 cells xenografted tumor. Tumor inhibition rate was about 17.2%, 48.6% and 62.1% for Nano Se, irinotecan and the combination of Nano Se and irinotecan, respectively. The beneficial effects of Nano Se for tumor therapy were mainly ascribed to selectively regulating Nrf2-ARE (antioxidant responsive elements) pathway in tumor tissues and normal tissues. Our results suggest Nano Se is a promising selenium species with potential application in cancer treatment. (C) 2014 Elsevier Ltd. All rights reserved.
学科主题	Engineering; Materials Science
收录类别	SCI
WOS记录号	WOS:000340984600011
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/224862]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Gao FP,Yuan Q,Gao J,et al. Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles[J]. BIOMATERIALS,2014,35(31):8854-8866.
APA	高福平.,袁卿.,高靓.,Gao, FP.,Yuan, Q.,...&高学云.(2014).Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles.BIOMATERIALS,35(31),8854-8866.
MLA	高福平,et al."Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles".BIOMATERIALS 35.31(2014):8854-8866.