Novel Insights into Combating Cancer Chemotherapy Resistance Using a Plasmonic Nanocarrier: Enhancing Drug Sensitiveness and Accumulation Simultaneously with Localized Mild Photothermal Stimulus of Femtosecond Pulsed Laser

	Novel Insights into Combating Cancer Chemotherapy Resistance Using a Plasmonic Nanocarrier: Enhancing Drug Sensitiveness and Accumulation Simultaneously with Localized Mild Photothermal Stimulus of Femtosecond Pulsed Laser
	Wang LM(王黎明); Lin XY(林晓影); Wang J(王静); Wang, LM; Lin, XY; Wang, J; Hu, ZJ; Ji, YL; Hou, S; Zhao, YL
刊名	ADVANCED FUNCTIONAL MATERIALS
	2014
卷号	24 期号:27 页码:4229-4239
英文摘要	Chemotherapy resistance remains a large obstacle to successful clinical cancer therapy, mainly due to little accumulation and low sensitivity of drugs and the effective clinical strategy still lacks. Herein, a novel yet simple strategy to combat cancer drug resistance using the plasmonic feature-based photothermal properties is reported. Rather than directly killing cancer cells using nanoparticle-mediated hyperthermia, for the first time, localized plasmonic heating of gold nanorod at a mild laser power density can modulate the drug-resistance related genes. This photothermal effect triggers higher expression of heat shock factor (HSF-1) trimers and depresses the expression of P-glycoprotein (Pgp) and mutant p53. In turn, both drug accumulation in the breast cancer resistant cells (MCF-7/ADR) and their sensitiveness to drugs can be greatly enhanced. Considering the universality and feasibility of this strategy, it points out a new unique way to challenge drug resistance.
学科主题	Chemistry; Science & Technology - Other Topics; Materials Science; Physics
收录类别	SCI
WOS记录号	WOS:000339713500003
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/224802]
专题	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Wang LM,Lin XY,Wang J,et al. Novel Insights into Combating Cancer Chemotherapy Resistance Using a Plasmonic Nanocarrier: Enhancing Drug Sensitiveness and Accumulation Simultaneously with Localized Mild Photothermal Stimulus of Femtosecond Pulsed Laser[J]. ADVANCED FUNCTIONAL MATERIALS,2014,24(27):4229-4239.
APA	王黎明.,林晓影.,王静.,Wang, LM.,Lin, XY.,...&陈春英.(2014).Novel Insights into Combating Cancer Chemotherapy Resistance Using a Plasmonic Nanocarrier: Enhancing Drug Sensitiveness and Accumulation Simultaneously with Localized Mild Photothermal Stimulus of Femtosecond Pulsed Laser.ADVANCED FUNCTIONAL MATERIALS,24(27),4229-4239.
MLA	王黎明,et al."Novel Insights into Combating Cancer Chemotherapy Resistance Using a Plasmonic Nanocarrier: Enhancing Drug Sensitiveness and Accumulation Simultaneously with Localized Mild Photothermal Stimulus of Femtosecond Pulsed Laser".ADVANCED FUNCTIONAL MATERIALS 24.27(2014):4229-4239.