Surface chemistry of gold nanorods: origin of cell membrane damage and cytotoxicity

	Surface chemistry of gold nanorods: origin of cell membrane damage and cytotoxicity
	Wang LM(王黎明); Jiang XM(江秀梅); Wang, LM; Jiang, XM; Ji, YL; Bai, R; Zhao, YL; Wu, XC; Chen, CY; Bai R(白茹)
刊名	NANOSCALE
	2013
卷号	5 期号:18 页码:8384-8391
英文摘要	We investigated how surface chemistry influences the interaction between gold nanorods (AuNRs) and cell membranes and the subsequent cytotoxicity arising from them in a serum-free cell culture system. Our results showed that the AuNRs coated with cetyl trimethylammonium bromide (CTAB) molecules can generate defects in the cell membrane and induce cell death, mainly due to the unique bilayer structure of CTAB molecules on the surface of the rods rather than their charge. Compared to CTAB-capped nanorods, positively charged polyelectrolyte-coated, i.e. poly(diallyldimethyl ammonium chloride) (PDDAC), AuNRs show improved biocompatibility towards cells. Thus, the present results indicate that the nature of surface molecules, especially their packing structures on the surface of AuNRs rather than surface charge, play a more crucial role in determining cytotoxicity. These findings about interfacial interactions could also explain the effects of internalized AuNRs on the structures or functions of organelles. This study will help understanding of the toxic nature of AuNRs and guide rational design of the surface chemistry of AuNRs for good biocompatibility in pharmaceutical therapy.
学科主题	Chemistry; Science & Technology - Other Topics; Materials Science; Physics
收录类别	SCI
WOS记录号	WOS:000323521000013
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/224308]
专题	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Wang LM,Jiang XM,Wang, LM,et al. Surface chemistry of gold nanorods: origin of cell membrane damage and cytotoxicity[J]. NANOSCALE,2013,5(18):8384-8391.
APA	王黎明.,江秀梅.,Wang, LM.,Jiang, XM.,Ji, YL.,...&陈春英.(2013).Surface chemistry of gold nanorods: origin of cell membrane damage and cytotoxicity.NANOSCALE,5(18),8384-8391.
MLA	王黎明,et al."Surface chemistry of gold nanorods: origin of cell membrane damage and cytotoxicity".NANOSCALE 5.18(2013):8384-8391.