Highly Sensitive Simultaneous Detection of Lead(II) and Barium(II) with G-Quadruplex DNA in alpha-Hemolysin Nanopore

	Highly Sensitive Simultaneous Detection of Lead(II) and Barium(II) with G-Quadruplex DNA in alpha-Hemolysin Nanopore
	Yang C(杨纯); Liu L(刘蕾); Yang, C; Liu, L; Zeng, T; Yang, DW; Yao, ZY; Zhao, YL; Wu, HC;; Yao ZY(姚志轶)
刊名	ANALYTICAL CHEMISTRY
	2013
卷号	85 期号:15 页码:7302-7307
英文摘要	Both Pb2+ and Ba2+ can bind with high affinity to some specific DNA sequences, inducing the formation of unimolecular G-quadruplex structures. Trans location of a DNA probe containing such sequences through an alpha-hemolysin nanopore in the presence of Pb2+ or Ba2+ . would result in much prolonged DNA translocation events. Quantification of these events can reveal the concentrations of Pb2+ or Ba2+ at as low as 0.8 nM. Besides, Pb2+ and Ba2+ in the solution can be simultaneously detected and individually identified. Furthermore, the probe is highly selective for Pb2+ and Ba2+ detection without interference from other metal ions. This sensing strategy can be extended to many other analytes which can bind to DNA molecules with high affinity.
学科主题	Chemistry
收录类别	SCI
WOS记录号	WOS:000323014000046
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/224295]
专题	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Yang C,Liu L,Yang, C,et al. Highly Sensitive Simultaneous Detection of Lead(II) and Barium(II) with G-Quadruplex DNA in alpha-Hemolysin Nanopore[J]. ANALYTICAL CHEMISTRY,2013,85(15):7302-7307.
APA	杨纯.,刘蕾.,Yang, C.,Liu, L.,Zeng, T.,...&吴海臣.(2013).Highly Sensitive Simultaneous Detection of Lead(II) and Barium(II) with G-Quadruplex DNA in alpha-Hemolysin Nanopore.ANALYTICAL CHEMISTRY,85(15),7302-7307.
MLA	杨纯,et al."Highly Sensitive Simultaneous Detection of Lead(II) and Barium(II) with G-Quadruplex DNA in alpha-Hemolysin Nanopore".ANALYTICAL CHEMISTRY 85.15(2013):7302-7307.