Surface Functionalized Gold Nanorods: Tracking and Observing Live Cell via Three Optical Signals

	Surface Functionalized Gold Nanorods: Tracking and Observing Live Cell via Three Optical Signals
	Qiu, XZ; Wang YL(王亚玲); Cui YY(崔艳艳); Wang, YL; Cui, YY; Sun, ZP; Liu, R; Huang, WH; Zhao, F; Zu, Y
刊名	JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
	2012
卷号	12 期号:9 页码:6893-6899
关键词	Gold Nanorods Multi-Signal Cell-Penetrating Peptide Raman Fluorescent MGITC Dark-Field
英文摘要	Surface functionalized gold nanorods (GNRs) with three optical signals and the ability to track and observe live cells was investigated. The Cetyltrimethyl Ammonium Bromide (CTAB) was used as the shape-directing agent to develop GNRs with uniform size and aspect ratio. The as-synthesized GNRs can strongly enhance the Raman signal of the attached MGITC on the GNRs. Polyethylene glycol (SH-PEG-COOH) and SH-PEG-FITC were attached with GNRs through ligand exchange with CTAB. They can stabilize the GNRs, reduce the cytotoxicity and provide fluorescence signal. A cell-penetrating peptide was covalently conjugated with SH-PEG-COOH to assist the GNRs to enter living cell. After cultured with the MCF-7 cells, the surfaced functionalized Au nanorods can enter the MCF-7 cells and be tracking with enhanced MGITC Raman signal, FITC fluorescence, and Rayleigh scatter signal.
学科主题	Chemistry; Science & Technology - Other Topics; Materials Science; Physics
收录类别	SCI
WOS记录号	WOS:000308856200004
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/224284]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Qiu, XZ,Wang YL,Cui YY,et al. Surface Functionalized Gold Nanorods: Tracking and Observing Live Cell via Three Optical Signals[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2012,12(9):6893-6899.
APA	Qiu, XZ.,王亚玲.,崔艳艳.,Wang, YL.,Cui, YY.,...&高学云.(2012).Surface Functionalized Gold Nanorods: Tracking and Observing Live Cell via Three Optical Signals.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,12(9),6893-6899.
MLA	Qiu, XZ,et al."Surface Functionalized Gold Nanorods: Tracking and Observing Live Cell via Three Optical Signals".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 12.9(2012):6893-6899.