Surface-Engineered Gold Nanorods: Promising DNA Vaccine Adjuvant for HIV-1 Treatment

	Surface-Engineered Gold Nanorods: Promising DNA Vaccine Adjuvant for HIV-1 Treatment
	Xu, LG; Liu, Y; Chen, ZY; Li, W; Liu, Y; Wang, LM; Liu, Y; Wu, XC; Ji, YL; Zhao, YL
刊名	NANO LETTERS
	2012
卷号	12 期号:4 页码:2003-2012
关键词	Gold nanorod surface chemistry adjuvant DNA vaccine HIV-1
英文摘要	With the intense international response to the AIDS pandemic, HIV vaccines have been extensively investigated but have failed due to issues of safety or efficacy in humans. Adjuvants for HIV/AIDS vaccines are under intense research but a rational design approach is still lacking. Nanomaterials represent an obvious opportunity in this field due to their unique physicochemical properties. Gold nanostructures are being actively studied as a promising and versatile platform for biomedical application. Herein, we report novel surface-engineered gold nanorods (NRs) used as promising DNA vaccine adjuvant for HIV treatment. We have exploited the effects of surface chemistry on the adjuvant activity of the gold nanorod by placing three kinds of molecules, that is, cetyltrimethylammonium bromide (CTAB), poly(diallydimethylammonium chloride) (PDDAC), and polyethyleneimine (PEI) on the surface of the nanorod. These PDDAC- or PEI-modified Au NRs can significantly promote cellular and humoral immunity as well as T cell proliferation through activating antigen-presenting cells if compared to naked HIV-1 Env plasmid DNA treatment in vivo. These findings have shed light on the rational design of low-toxic nanomaterials as a versatile platform for vaccine nanoadjuvants/delivery systems.
学科主题	Chemistry; Science & Technology - Other Topics; Materials Science; Physics
收录类别	SCI
WOS记录号	WOS:000302524600044
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/224183]
专题	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Xu, LG,Liu, Y,Chen, ZY,et al. Surface-Engineered Gold Nanorods: Promising DNA Vaccine Adjuvant for HIV-1 Treatment[J]. NANO LETTERS,2012,12(4):2003-2012.
APA	Xu, LG.,Liu, Y.,Chen, ZY.,Li, W.,Liu, Y.,...&赵宇亮.(2012).Surface-Engineered Gold Nanorods: Promising DNA Vaccine Adjuvant for HIV-1 Treatment.NANO LETTERS,12(4),2003-2012.
MLA	Xu, LG,et al."Surface-Engineered Gold Nanorods: Promising DNA Vaccine Adjuvant for HIV-1 Treatment".NANO LETTERS 12.4(2012):2003-2012.