Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles

	Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles
	Xu, Q; Liu, YX; Su, SS; Li, W; Chen, CY; Wu, Y; 李炜(多
刊名	BIOMATERIALS
	2012
卷号	33 期号:5 页码:1627-1639
关键词	Hyperbranched copolymer nanoparticle Tumor-targeting cRGDfK Transferrin Intrinsic fluorescence Controlled drug release
英文摘要	Targeted delivery strategies are becoming increasingly important. Herein, a novel hyperbranched amphiphilic poly[(amine-ester)-co-(D,L-lactide)]/1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer (HPAE-co-PLA/DPPE) with RGD peptide (cRGDfK) and transferrin (If) on the periphery was synthesized and used to prepare paclitaxel-loaded nanoparticles (NPs) for dual-targeting chemotherapy. These NPs show satisfactory size distribution, high encapsulated efficiency and a pH-dependent release profile. The intrinsic fluorescence of the hyperbranched copolymer renders the detection and tracking of NPs in vitro and in vivo conveniently. In vitro cytotoxicity studies proved that the presence of cRGDfK enhanced the cytotoxic efficiency by 10 folds in delta(v)beta(3) integrin over-expressed human umbilical vein endothelial cells, while If improved cytotoxicity by 2 folds in If receptor over-expressed human cervical carcinoma cells. The drug-loaded NPs can be efficiently transported into the vascular endothelial cells and the target tumor cells. These results indicate that the cRGDfK and If decorated HPAE-co-PLA/DPPE could deliver chemotherapies specifically inside the cell via receptor-mediated endocytosis with greater efficacy. Therefore, such a fluorescent nanocarrier prepared from non-cytotoxic and biodegradable polymers is promising for drug delivery in tumor therapy. (C) 2011 Elsevier Ltd. All rights reserved.
学科主题	Engineering; Materials Science
收录类别	SCI
WOS记录号	WOS:000300474000042
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/224158]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Xu, Q,Liu, YX,Su, SS,et al. Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles[J]. BIOMATERIALS,2012,33(5):1627-1639.
APA	Xu, Q.,Liu, YX.,Su, SS.,Li, W.,Chen, CY.,...&李炜.(2012).Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles.BIOMATERIALS,33(5),1627-1639.
MLA	Xu, Q,et al."Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles".BIOMATERIALS 33.5(2012):1627-1639.