Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level

	Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level
	Zuo, GH; Kang, SG; Xiu, P; Zhao, YL; Zhou, RH; Zhao YL(赵宇亮)
刊名	SMALL
	2013
卷号	9 期号:9-10 SI 页码:1546-1556
关键词	nanotoxicology proteinnanoparticle interactions molecular simulations carbon nanotubes
英文摘要	The widespread application of nanomaterials has spurred an interest in the study of interactions between nanoparticles and proteins due to the biosafety concerns of these nanomaterials. In this review, a summary is presented of some of the recent studies on this important subject, especially on the interactions of proteins with carbon nanotubes (CNTs) and metallofullerenols. Two potential molecular mechanisms have been proposed for CNTs' inhibition of protein functions. The driving forces of CNTs' adsorption onto proteins are found to be mainly hydrophobic interactions and the so-called stacking between CNTs' carbon rings and proteins' aromatic residues. However, there is also recent evidence showing that endohedral metallofullerenol Gd@C82(OH)22 can be used to inhibit tumor growth, thus acting as a potential nanomedicine. These recent findings have provided a better understanding of nanotoxicity at the molecular level and also suggested therapeutic potential by using nanoparticles' cytotoxicity against cancer cells.
学科主题	Chemistry; Science & Technology - Other Topics; Materials Science; Physics
收录类别	SCI
WOS记录号	WOS:000319076000011
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/224149]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Zuo, GH,Kang, SG,Xiu, P,et al. Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level[J]. SMALL,2013,9(9-10 SI):1546-1556.
APA	Zuo, GH,Kang, SG,Xiu, P,Zhao, YL,Zhou, RH,&赵宇亮.(2013).Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level.SMALL,9(9-10 SI),1546-1556.
MLA	Zuo, GH,et al."Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level".SMALL 9.9-10 SI(2013):1546-1556.