Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway

	Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway
	Yang, KN; Cao, WP; Hao, XH; Xue, X; Zhao, J; Liu, J; Zhao, YL; Meng, J; Sun, BY; Zhang, JC
刊名	NANOSCALE
	2013
卷号	5 期号:3 页码:1205-1212
英文摘要	Although endohedral metallofullerenol [Gd@C-82(OH)(22)](n) nanoparticles have anti-tumor efficiency and mostly deposit in the bones of mice, how these nanoparticles act in bone marrow stromal cells (MSCs) remains largely unknown. Herein, we observed that [Gd@C-82(OH)(22)](n) nanoparticles facilitated the differentiation of MSCs toward osteoblasts, as evidenced by the enhancement of alkaline phosphatase (ALP) activity and mineralized nodule formation upon [Gd@C-82(OH)(22)](n) nanoparticle treatment. Mechanistically, the effect of [Gd@C-82(OH)(22)](n) nanoparticles on ALP activity was inhibited by the addition of noggin as an inhibitor of the BMP signaling pathway. Moreover, the in vivo results of the ovariectomized rats further indicated that [Gd@C-82(OH)(22)](n) nanoparticles effectively improved bone density and prevented osteoporosis.
学科主题	Chemistry; Science & Technology - Other Topics; Materials Science; Physics
收录类别	SCI
WOS记录号	WOS:000313803000051
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/224116]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Yang, KN,Cao, WP,Hao, XH,et al. Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway[J]. NANOSCALE,2013,5(3):1205-1212.
APA	Yang, KN.,Cao, WP.,Hao, XH.,Xue, X.,Zhao, J.,...&孙宝云.(2013).Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway.NANOSCALE,5(3),1205-1212.
MLA	Yang, KN,et al."Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway".NANOSCALE 5.3(2013):1205-1212.