How to split a G-quadruplex for DNA detection: new insight into the formation of DNA split G-quadruplex

	How to split a G-quadruplex for DNA detection: new insight into the formation of DNA split G-quadruplex
	Zhu,Jinbo; Zhang,Libing; Dong,Shaojun; Wang,Erkang
刊名	chemical science
	2015
卷号	6 期号:8 页码:4822-4827
关键词	STRAND DISPLACEMENT LABEL-FREE POTASSIUM-ION LOGIC-CIRCUIT JAK2 V617F DNAZYME PROBES IDENTIFICATION ACID NANOCLUSTERS
通讯作者	wang,ek
英文摘要	here, we get a new insight into the formation of a split g-quadruplex from the viewpoints of the split mode and guanine base number. an unusual result is that the split mode 4 : 8 performed best in six split modes, including the frequently used mode 1 : 3 and 2 : 2 in the split g-quadruplex enhanced fluorescence assay. circular dichroism spectra verified the conclusion. the application of the split g-quadruplex based assay in dna detection was performed on the point mutations of the jak2 v617f and hbb genes. a multi-target analysis method based on a pool of g-segments split from t30695 (gggtgggtgggtgggt) by the magic "law of 4 : 8" was established.
收录类别	SCI
语种	英语
WOS记录号	WOS:000357931700052
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64579]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhu,Jinbo,Zhang,Libing,Dong,Shaojun,et al. How to split a G-quadruplex for DNA detection: new insight into the formation of DNA split G-quadruplex[J]. chemical science,2015,6(8):4822-4827.
APA	Zhu,Jinbo,Zhang,Libing,Dong,Shaojun,&Wang,Erkang.(2015).How to split a G-quadruplex for DNA detection: new insight into the formation of DNA split G-quadruplex.chemical science,6(8),4822-4827.
MLA	Zhu,Jinbo,et al."How to split a G-quadruplex for DNA detection: new insight into the formation of DNA split G-quadruplex".chemical science 6.8(2015):4822-4827.