Metabolic pathways of decabromodiphenyl ether (BDE209) in rainbow trout (Oncorhynchus mykiss) via intraperitoneal injection

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境水质学国家重点实验室

	Metabolic pathways of decabromodiphenyl ether (BDE209) in rainbow trout (Oncorhynchus mykiss) via intraperitoneal injection
	Feng, Chenglian; Xu, Yiping; Zha, Jinmiao; Li, Jian; Wu, Fengchang; Wang, Zijian
刊名	ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
	2015-03
卷号	39 期号:2 页码:536-544
关键词	Decabromodiphenyl ether (BDE209) Rainbow trout (Oncorhynchus mykiss) Metabolic pathways OH-BDEs MeO-BDEs
英文摘要	Decabromodiphenyl ether (BDE209) was of great concern due to its biotransformation in different organisms. However, most studies devoted to the metabolic intermediates of BDE209, less has been done on the metabolic pathways in vivo, especially on the relationships among debrominated-BDEs, OH-BDEs and MeO-BDEs. In this study, the metabolic pathways and intermediates of BDE209 in rainbow trout (Oncorhynchus mykiss) were investigated, and the time-dependent transformations of the metabolites were also examined. The primary debrominated metabolites were BDE47, 49, 99, 197, 207; the main MeO-BDEs were MeO-BDE47, MeO-BDE68 and MeO-BDE100; OH-BDEs were primarily composed of OH-BDE28 and OH-BDE42. From the time-dependent and dose-effect relationships, the debromination should be followed by hydroxylation, and then by methoxylation. The increasing in body burden of MeO-BDEs corresponded to the decreasing of OH-BDEs, which could indirectly prove the inter-conversion between OH-BDEs and MeO-BDEs. This study would motivate the future research of toxicological mechanisms of BDEs. (C) 2015 Elsevier B.V. All rights reserved.
研究领域[WOS]	Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology
WOS记录号	WOS:000353929900007
公开日期	2016-03-15
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/32801]
专题	生态环境研究中心_环境水质学国家重点实验室
推荐引用方式 GB/T 7714	Feng, Chenglian,Xu, Yiping,Zha, Jinmiao,et al. Metabolic pathways of decabromodiphenyl ether (BDE209) in rainbow trout (Oncorhynchus mykiss) via intraperitoneal injection[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2015,39(2):536-544.
APA	Feng, Chenglian,Xu, Yiping,Zha, Jinmiao,Li, Jian,Wu, Fengchang,&Wang, Zijian.(2015).Metabolic pathways of decabromodiphenyl ether (BDE209) in rainbow trout (Oncorhynchus mykiss) via intraperitoneal injection.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,39(2),536-544.
MLA	Feng, Chenglian,et al."Metabolic pathways of decabromodiphenyl ether (BDE209) in rainbow trout (Oncorhynchus mykiss) via intraperitoneal injection".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 39.2(2015):536-544.