Differential Accumulation and Elimination Behavior of Perfluoroalkyl Acid Isomers in Occupational Workers in a Manufactory in China

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Differential Accumulation and Elimination Behavior of Perfluoroalkyl Acid Isomers in Occupational Workers in a Manufactory in China
	Gao, Yan; Fu, Jianjie; Cao, Huiming; Wang, Yawei; Zhang, Aiqian; Liang, Yong; Thanh Wang; Zhao, Chunyan; Jiang, Guibin
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2015-06-02
卷号	49 期号:11 页码:6953-6962
英文摘要	In this study, serum and urine samples were collected from 36 occupational workers in a fluorochemical manufacturing plant in China from 2008 to 2012 to evaluate the body burden and possible elimination of linear and branched perfluoroalkyl acids (PFAAs). Indoor dust, total suspended particles (TSP), diet, and drinking water samples were also collected to trace the occupational exposure pathway to PFAA isomers. The geometric mean concentrations of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS) isomers in the serum were 1386, 371, and 863 ng mL(-1), respectively. The linear isomer of PFOS, PFOA, and PFHxS was the most predominant PFAA in the serum, with mean proportions of 63.3, 91.1, and 92.7% respectively, which were higher than the proportions in urine. The most important exposure routes to PFAA isomers in the occupational workers were considered to be the intake of indoor dust and TSP. A renal clearance estimation indicated that branched PFAA isomers had a higher renal clearance rate than did the corresponding linear isomers. Molecular docking modeling implied that linear PFOS (n-PFOS) had a stronger interaction with human serum albumin (HSA) than branched isomers did, which could decrease the proportion of n-PFOS in the blood of humans via the transport of HSA.
研究领域[WOS]	Engineering, Environmental ; Environmental Sciences
WOS记录号	WOS:000355779100070
公开日期	2016-03-15
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/32554]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Gao, Yan,Fu, Jianjie,Cao, Huiming,et al. Differential Accumulation and Elimination Behavior of Perfluoroalkyl Acid Isomers in Occupational Workers in a Manufactory in China[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2015,49(11):6953-6962.
APA	Gao, Yan.,Fu, Jianjie.,Cao, Huiming.,Wang, Yawei.,Zhang, Aiqian.,...&Jiang, Guibin.(2015).Differential Accumulation and Elimination Behavior of Perfluoroalkyl Acid Isomers in Occupational Workers in a Manufactory in China.ENVIRONMENTAL SCIENCE & TECHNOLOGY,49(11),6953-6962.
MLA	Gao, Yan,et al."Differential Accumulation and Elimination Behavior of Perfluoroalkyl Acid Isomers in Occupational Workers in a Manufactory in China".ENVIRONMENTAL SCIENCE & TECHNOLOGY 49.11(2015):6953-6962.