Chemical and Toxicological Characterization of Halobenzoquinones, an Emerging Class of Disinfection Byproducts

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Chemical and Toxicological Characterization of Halobenzoquinones, an Emerging Class of Disinfection Byproducts
	Li, Jinhua; Wang, Wei; Moe, Birget; Wang, Hailin; Li, Xing-Fang
刊名	CHEMICAL RESEARCH IN TOXICOLOGY
	2015-03
卷号	28 期号:3 页码:306-318
英文摘要	Halobenzoquinones (HBQs), a new class of disinfection byproducts (DBPs), occur widely in treated drinking water and recreational water. The main concern regarding human exposure to DBPs stems from epidemiological studies that have consistently linked the consumption of chlorinated:drinking water with: an increased risk of developing bladder cancer. The U.S. Environmental Protection Agency and Health Canada have set regulations on the amount of DBPs in drinking water to minimize the risk. However, these regulated DBPs do not account for the increased risk of bladder cancer because they have different target organs or lower magnitudes of risk based on animal carcinogenesis studies. Because of the pervasive exposure to DBPs, identification of DBPs relevant to human health has become one of the important research targets to address DBP-associated health concerns. Quantitative structure toxicity relationship (QSTR) analysis has predicted HBQs to be potential bladder carcinogens. Therefore; this' perspective focuses on the chemical and, toxicological characterization of IHBQs. In vitro cytotoxicity experiments have shown that HBQs induce greater cytotoxicity and/or greater developmental toxicity than most of the regulated Dill's. Cellular mechanistic studies indicate that HBQs are capable of producing reactive oxygen species (ROS) either within cells or in solution, depleting cellular glutathione levels, and influencing cellular antioxidant enzymes, which further induces Oxidative stress and oxidative damage to cellular proteins and DNA. Oxidative damage to DNA was demonstrated in the form of significant increases in cellular levels of 8-hydroxydeoxyguanosine (8-OHdG), DNA strand breaks; and apurinic/apyrimidinic (AP) sites. HBQs can also form DNA adducts, affect genome-wide DNA methylation, and inhibit DNA repair enzymes. These findings demonstrate that HBQs are highly cytotoxic and potentially genotoxic and carcinogenic, although in vivo data corroborating this is not available. To fully understand the potential adverse health effects and cancer risk due to HBQ exposure, multidisciplinary research is required regarding human exposure, health risk assessment, and toxicological mechanisms of HBQs.
研究领域[WOS]	Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Toxicology
WOS记录号	WOS:000351326400005
公开日期	2016-03-15
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/32535]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Li, Jinhua,Wang, Wei,Moe, Birget,et al. Chemical and Toxicological Characterization of Halobenzoquinones, an Emerging Class of Disinfection Byproducts[J]. CHEMICAL RESEARCH IN TOXICOLOGY,2015,28(3):306-318.
APA	Li, Jinhua,Wang, Wei,Moe, Birget,Wang, Hailin,&Li, Xing-Fang.(2015).Chemical and Toxicological Characterization of Halobenzoquinones, an Emerging Class of Disinfection Byproducts.CHEMICAL RESEARCH IN TOXICOLOGY,28(3),306-318.
MLA	Li, Jinhua,et al."Chemical and Toxicological Characterization of Halobenzoquinones, an Emerging Class of Disinfection Byproducts".CHEMICAL RESEARCH IN TOXICOLOGY 28.3(2015):306-318.