Facile Construction of pH- and Redox-Responsive Micelles from a Biodegradable Poly(beta-hydroxyl amine) for Drug Delivery

	Facile Construction of pH- and Redox-Responsive Micelles from a Biodegradable Poly(beta-hydroxyl amine) for Drug Delivery
	Li, Dawei 1,2; Bu, Yazhong 1; Zhang, Lining 3; Wang, Xing 1; Yang, Yanyu 1; Zhuang, Yaping 1; Yang, Fei 1; Shen, Hong 1; Wu, Decheng 1
刊名	BIOMACROMOLECULES
	2016
卷号	17 期号:1 页码:291-300
英文摘要	Here we demonstrate a type of pH and reduction dual-sensitive biodegradable micelles, which were self-assembled by a cationic polymer in an aqueous solution. Due to tumor cells or tissues showing low pH and high reduction concentration, these micelles possessed specific tumor targetability and maximal drug-release controllability inside tumor cells upon changes in physical and chemical environments, but presented good stability at physiological conditions. CCK-8 assay showed that the DOX-loaded micelles had a similar cytotoxicity for MCF-7 tumor cells as free DOX, and blank micelles had a very low cytotoxicity to the cells. Fluorescent microscopy observation revealed that the drug-loaded Micelles could be quickly internalized by endosomes to inhibit cancer cell growth. These results indicated these biodegradable micelles, as a novel and effective pH- and redox-responsive nanocarrier, have a potential to improve drug delivery and enhance the antitumor efficacy.
收录类别	SCI
语种	英语
公开日期	2016-03-15
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/29777]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.309th Hosp PLA, Dept Orthopaed, Beijing 100094, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, Ctr Rehabil, Beijing 100853, Peoples R China
推荐引用方式 GB/T 7714	Li, Dawei,Bu, Yazhong,Zhang, Lining,et al. Facile Construction of pH- and Redox-Responsive Micelles from a Biodegradable Poly(beta-hydroxyl amine) for Drug Delivery[J]. BIOMACROMOLECULES,2016,17(1):291-300.
APA	Li, Dawei.,Bu, Yazhong.,Zhang, Lining.,Wang, Xing.,Yang, Yanyu.,...&Wu, Decheng.(2016).Facile Construction of pH- and Redox-Responsive Micelles from a Biodegradable Poly(beta-hydroxyl amine) for Drug Delivery.BIOMACROMOLECULES,17(1),291-300.
MLA	Li, Dawei,et al."Facile Construction of pH- and Redox-Responsive Micelles from a Biodegradable Poly(beta-hydroxyl amine) for Drug Delivery".BIOMACROMOLECULES 17.1(2016):291-300.