Diterpenoid constituents of Euphorbia macrorrhiza

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	Diterpenoid constituents of Euphorbia macrorrhiza
	Gao, J (Gao, Jie); Chen, QB (Chen, Qi-Bin); Liu, YQ (Liu, Yong-Qiang); Xin, XL (Xin, Xue-Lei); Yili, A (Yili, Ablimiti); Aisa, HA (Aisa, Haji Akber)
刊名	PHYTOCHEMISTRY
	2016
卷号	122 期号:2 页码:246-253
关键词	Euphorbia macrorrhiza CA Mey Euphorbiaceae Diterpenoids Cytotoxicity Multidrug resistance reversal activity
通讯作者	Aisa, HA
英文摘要	Ten diterpenoids, named macrorilone A-B, macroripremyrsinone A, macrorilathyrone A-B, macrorieuphorone A-B and macroricasbalone A-C, together with ten known diterpenoids, jatrophalone, sikkimenoids A-D, jatrophodione A, latilagascenes F, jolkinol B, 15 beta-O-benzoyl-5 alpha-hydroxyisolathyrol and jatrophalactone were isolated from the whole plant of Euphorbia macrorrhiza C.A. Mey. These diterpenoids belong to six skeleton-types, including jatropholane, premyrsinane, lathyrane, euphoractin, casbene and rhamnofolane diterpenoids. Their structures were elucidated by extensive analysis of 1D, 2D NMR and HRESIMS spectroscopic data. The absolute configurations of macrorilone B, macroripremyrsinone A and macrorilathyrone A were established by comparing their experimental and calculated electronic circular dichroism (ECD) spectra. Several of the isolated compounds exhibited weak cytotoxicity against the KB and KBv200 cell lines with IC50 values ranging from 21.19 to 47.87 mu M. Some also showed multidrug resistance (MDR) reversal activity, among which macrorilathyrone B exhibited a remarkable inhibitory effect on P-gp-mediated drug exclusion.
收录类别	SCI
WOS记录号	WOS:000369460200027
内容类型	期刊论文
源URL	[http://ir.xjipc.cas.cn/handle/365002/4342]
专题	新疆理化技术研究所_资源化学研究室
作者单位	Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China;Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Gao, J ,Chen, QB ,Liu, YQ ,et al. Diterpenoid constituents of Euphorbia macrorrhiza[J]. PHYTOCHEMISTRY,2016,122(2):246-253.
APA	Gao, J ,Chen, QB ,Liu, YQ ,Xin, XL ,Yili, A ,&Aisa, HA .(2016).Diterpenoid constituents of Euphorbia macrorrhiza.PHYTOCHEMISTRY,122(2),246-253.
MLA	Gao, J ,et al."Diterpenoid constituents of Euphorbia macrorrhiza".PHYTOCHEMISTRY 122.2(2016):246-253.