Control of response reliability by parvalbumin-expressing interneurons in visual cortex

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	Control of response reliability by parvalbumin-expressing interneurons in visual cortex
	Zhu, YJ; Qiao, WH; Liu, KF; Zhong, HY; Yao, HS
刊名	NATURE COMMUNICATIONS
	2015
卷号	6 期号:1 页码:6802-6802
关键词	CAT STRIATE CORTEX NETWORKS IN-VIVO CORTICAL ACTIVITY AUDITORY-CORTEX FEEDFORWARD INHIBITION GABAERGIC INTERNEURONS SPATIAL INTEGRATION RECEPTIVE-FIELDS PYRAMIDAL CELLS NATURAL STIMULI
通讯作者	Yao, HS (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,haishanyao@ion.ac.cn
英文摘要	The responses of visual cortical neurons to natural stimuli are both reliable and sparse. These properties require inhibition, yet the contribution of specific types of inhibitory neurons is not well understood. Here we demonstrate that optogenetic suppression of parvalbumin (PV)-but not somatostatin (SOM)-expressing interneurons reduces response reliability in the primary visual cortex of anaesthetized and awake mice. PV suppression leads to increases in the low firing rates and decreases in the high firing rates of cortical neurons, resulting in an overall reduction of the signal-to-noise ratio (SNR). In contrast, SOM suppression generally increases the overall firing rate for most neurons, without affecting the SNR. Further analysis reveals that PV, but not SOM, suppression impairs neural discrimination of natural stimuli. Together, these results reveal a critical role for PV interneurons in the formation of reliable visual cortical representations of natural stimuli.
学科主题	Multidisciplinary Sciences
WOS标题词	Science & Technology - Other Topics
收录类别	SCI
语种	英语
WOS记录号	WOS:000353702500042
公开日期	2016-02-26
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/3954]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Zhu, YJ,Qiao, WH,Liu, KF,et al. Control of response reliability by parvalbumin-expressing interneurons in visual cortex[J]. NATURE COMMUNICATIONS,2015,6(1):6802-6802.
APA	Zhu, YJ,Qiao, WH,Liu, KF,Zhong, HY,&Yao, HS.(2015).Control of response reliability by parvalbumin-expressing interneurons in visual cortex.NATURE COMMUNICATIONS,6(1),6802-6802.
MLA	Zhu, YJ,et al."Control of response reliability by parvalbumin-expressing interneurons in visual cortex".NATURE COMMUNICATIONS 6.1(2015):6802-6802.