Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes

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	Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes
	Bian, WJ; Miao, WY; He, SJ; Qiu, Z; Yu, X
刊名	CELL
	2015
卷号	162 期号:4 页码:808-822
关键词	LONG-TERM POTENTIATION DENDRITIC SPINES SYNAPTIC PLASTICITY N-CADHERIN CEREBRAL-CORTEX IN-VIVO NEUROPSYCHIATRIC DISORDERS HIPPOCAMPAL DENDRITES DIVERSE REGIONS ADULT NEOCORTEX
通讯作者	Yu, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, Inst Neurosci,State Key Lab Neurosci, Shanghai 200031, Peoples R China.,yuxiang@ion.ac.cn
英文摘要	Dendritic spines are postsynaptic compartments of excitatory synapses that undergo dynamic changes during development, including rapid spinogenesis in early postnatal life and significant pruning during adolescence. Spine pruning defects have been implicated in developmental neurological disorders such as autism, yet much remains to be uncovered regarding its molecular mechanism. Here, we show that spine pruning and maturation in the mouse somatosensory cortex are coordinated via the cadherin/catenin cell adhesion complex and bidrectionally regulated by sensory experience. We further demonstrate that locally enhancing cadherin/catenin-dependent adhesion or photo-stimulating a contacting channelrhodopsin-expressing axon stabilized the manipulated spine and eliminated its neighbors, an effect requiring cadherin/catenin-dependent adhesion. Importantly, we show that differential cadherin/catenin-dependent adhesion between neighboring spines biased spine fate in vivo. These results suggest that activity-induced inter-spine competition for beta-catenin provides specificity for concurrent spine maturation and elimination and thus is critical for the molecular control of spine pruning during neural circuit refinement.
学科主题	Biochemistry & Molecular Biology; Cell Biology
WOS标题词	Biochemistry & Molecular Biology ; Cell Biology
收录类别	SCI
语种	英语
WOS记录号	WOS:000359741400014
公开日期	2016-02-26
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/3935]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Bian, WJ,Miao, WY,He, SJ,et al. Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes[J]. CELL,2015,162(4):808-822.
APA	Bian, WJ,Miao, WY,He, SJ,Qiu, Z,&Yu, X.(2015).Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes.CELL,162(4),808-822.
MLA	Bian, WJ,et al."Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes".CELL 162.4(2015):808-822.