Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis

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	Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis
	Zhou, JJ; Cheng, C; Qiu, ZL; Zhou, WH; Cheng, GQ
刊名	NEUROSCIENCE BULLETIN
	2015
卷号	31 期号:6 页码:763-768
关键词	INJURY IN-VIVO SYSTEMIC INFLAMMATION MICROGLIAL RESPONSE ACTIVATED MICROGLIA CX43 HEMICHANNELS DEVELOPING BRAIN PRETERM INFANTS INFECTION CHANNELS
通讯作者	Cheng, GQ (reprint author), Fudan Univ, Childrens Hosp, Dept Neonatol, Shanghai 201102, Peoples R China.,gqchengcm@sina.com
英文摘要	Neonatal sepsis is common in neonatal intensive care units, often complicated by injury to the immature brain. Previous studies have shown that the expression of the gap junction protein connexin 43 (Cx43) in the brain decreases when stimulated by neuro-inflammatory drugs such as lipopolysaccharide (LPS). Here we showed that partial deletion of Cx43 in astrocytes resulted in weakened inflammatory responses. The up-regulation of pro-inflammatory cytokines was significantly reduced in mice with partial deletion of Cx43 in astrocytes compared with wild-type littermates after systemic LPS injection. Moreover, microglial activation was inhibited in mice with partial deletion of Cx43. These results showed that Cx43 in astrocytes plays a critical role in neuro-inflammatory responses. This work provides a potential therapeutic target for inhibiting neuro-inflammatory responses in neonatal sepsis.
学科主题	Neurosciences
WOS标题词	Neurosciences & Neurology
收录类别	SCI
语种	英语
WOS记录号	WOS:000365763300013
公开日期	2016-02-26
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/3924]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Zhou, JJ,Cheng, C,Qiu, ZL,et al. Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis[J]. NEUROSCIENCE BULLETIN,2015,31(6):763-768.
APA	Zhou, JJ,Cheng, C,Qiu, ZL,Zhou, WH,&Cheng, GQ.(2015).Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis.NEUROSCIENCE BULLETIN,31(6),763-768.
MLA	Zhou, JJ,et al."Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis".NEUROSCIENCE BULLETIN 31.6(2015):763-768.