Hexacyclic monoterpenoid indole alkaloids from Rauvolfia verticillata

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Hexacyclic monoterpenoid indole alkaloids from Rauvolfia verticillata
	Gao, Yuan; Yu, Ai-Lin; Li, Gen-Tao; Hai, Ping; Li, Yan; Liu, Ji-Kai; Wang, Fei
刊名	FITOTERAPIA
	2015-12-01
卷号	107 页码:44-48
关键词	Rauvolfia verticillata Monoterpenoid indole alkaloid Rauvovertine Cytotoxicity
英文摘要	Five new hexacyclic monoterpenoid indole alkaloids, rauvovertine A (1), 17-epi-rauvovertine A (2), rauvovertine B (3), 17-epi-rauvovertine B (4), and rauvovertine C (5) together with 17 known analogues were isolated from the stems of Rauvolfia verticillata. Compounds 1/2 and 3/4 were obtained as C-17 epimeric mixtures due to rapid hemiacetal tautomerism in solution. The structures of 1-5 were established by spectroscopic analysis and with the aid of molecular modeling. The new alkaloids were evaluated for their cytotoxicity in vitro against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. (C) 2015 Elsevier B.V. All rights reserved.
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	STRUCTURE ELUCIDATION ; RAUWOLFIA ; SARPAGINE ; IDENTIFICATION ; CONSTITUENTS ; SERPENTINA ; PERAKSINE ; LEAVES
收录类别	SCI
语种	英语
WOS记录号	WOS:000367113000006
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/25346]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Gao, Yuan,Yu, Ai-Lin,Li, Gen-Tao,et al. Hexacyclic monoterpenoid indole alkaloids from Rauvolfia verticillata[J]. FITOTERAPIA,2015,107:44-48.
APA	Gao, Yuan.,Yu, Ai-Lin.,Li, Gen-Tao.,Hai, Ping.,Li, Yan.,...&Wang, Fei.(2015).Hexacyclic monoterpenoid indole alkaloids from Rauvolfia verticillata.FITOTERAPIA,107,44-48.
MLA	Gao, Yuan,et al."Hexacyclic monoterpenoid indole alkaloids from Rauvolfia verticillata".FITOTERAPIA 107(2015):44-48.