Cytotoxic limonoids from Trichilia americana leaves

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cytotoxic limonoids from Trichilia americana leaves
	Ji,Kai-Long; Zhang,Ping; Li,Xiao-Nian; Guo,Juan; Hu,Hua-Bin; Xiao,Chun-Fen; Xie,Xiang-Qun; Xu,You-Kai
刊名	PHYTOCHEMISTRY
	2015-10-01
卷号	118 页码:61-67
关键词	Trichilia americana Meliaceae Cedrelone limonoids Cytotoxicity
英文摘要	Ten cedrelone limonoids were isolated from the leaves of Trichilia americana. These compounds include americanolides A-D (1-4), 1,2-dihydrodeacetylhirtin (5), 1 alpha-hydroxy-1,2-dihydrodeacetylhirtin (6), 1ahydroxy-1,2-dihydrohirtin (7), 1 alpha-methoxy-1,2-dihydrodeacetylhirtin (8), 11 beta-hydroxy-12 alpha-propanoyloxycedrelone (9), and 1 alpha,11 beta-dihydroxy-1,2-dihydrocedrelone (10), as well as two previously reported compounds, deacetylhirtin (11) and hirtin (12). Their structures were characterized on the basis of spectroscopic studies, and the assignment of the absolute configuration of americanolide A (1) was supported by single-crystal X-ray diffraction studies. The cytotoxic activities of all isolated compounds were also evaluated against five human tumour cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480) using an MTS assay. Compounds 11 and 12 showed significant cytotoxicity with IC50 values ranging from 0.1 to 0.5 mu M, and compounds 5, 6, 7, 8, 9, and 10 exhibited potent or selective cytotoxic activity with IC50 values ranging from 1.0 to 39.6 mu M. (C) 2015 Elsevier Ltd. All rights reserved.
类目[WOS]	Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]	Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]	NITRIC-OXIDE PRODUCTION ; WALSURA-YUNNANENSIS ; SPODOPTERA-LITURA ; TETRANORTRITERPENOIDS ; CONNAROIDES ; ANTIFEEDANT ; MELIACEAE ; EXTRACT
收录类别	SCI
语种	英语
WOS记录号	WOS:000363076800008
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/25206]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Ji,Kai-Long,Zhang,Ping,Li,Xiao-Nian,et al. Cytotoxic limonoids from Trichilia americana leaves[J]. PHYTOCHEMISTRY,2015,118:61-67.
APA	Ji,Kai-Long.,Zhang,Ping.,Li,Xiao-Nian.,Guo,Juan.,Hu,Hua-Bin.,...&Xu,You-Kai.(2015).Cytotoxic limonoids from Trichilia americana leaves.PHYTOCHEMISTRY,118,61-67.
MLA	Ji,Kai-Long,et al."Cytotoxic limonoids from Trichilia americana leaves".PHYTOCHEMISTRY 118(2015):61-67.