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	A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation
	Jiang,Shiyou; Du,Jiacheng; Kong,Qinghua; Li,Chaocui; Li,Yan; Sun,Handong; Pu,Jianxin; Mao,Bingyu
刊名	PLOS ONE
	2015-10-06
卷号	10期号:10
英文摘要	The Hedgehog (Hh) signaling pathway plays important roles in the tumorigenesis of multiple cancers and is a key target for drug discovery. In a screen of natural products extracted from Chinese herbs, we identified eight ent-Kaurane diterpenoids and two triterpene dilactones as novel Hh pathway antagonists. Epistatic analyses suggest that these compounds likely act at the level or downstream of Smoothened (Smo) and upstream of Suppressor of Fused (Sufu). The ent-Kauranoid-treated cells showed elongated cilia, suppressed Smo trafficking to cilia, and mitotic defects, while the triterpene dilactones had no effect on the cilia and ciliary Smo. These ent-Kaurane diterpenoids provide new prototypes of Hh inhibitors, and are valuable probes for deciphering the mechanisms of Smo ciliary transport and ciliogenesis.
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	SMALL-MOLECULE INHIBITORS ; BASAL-CELL CARCINOMA ; TRITERPENE DILACTONES ; PATHWAY INHIBITOR ; PROTEIN KIF7 ; MITOSIS ; MEDULLOBLASTOMA ; CILIOGENESIS ; SUPPRESSOR ; BINDING
收录类别	SCI
语种	英语
WOS记录号	WOS:000362510300064
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/25186]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Jiang,Shiyou,Du,Jiacheng,Kong,Qinghua,et al. A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation[J]. PLOS ONE,2015,10(10).
APA	Jiang,Shiyou.,Du,Jiacheng.,Kong,Qinghua.,Li,Chaocui.,Li,Yan.,...&Mao,Bingyu.(2015).A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation.PLOS ONE,10(10).
MLA	Jiang,Shiyou,et al."A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation".PLOS ONE 10.10(2015).

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