Novel 3-substituted fluorine imidazolium/triazolium salt derivatives: synthesis and antitumor activity

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Novel 3-substituted fluorine imidazolium/triazolium salt derivatives: synthesis and antitumor activity
	Liu, Jin-Mei 1; Wang, Min 2; Zhou, Yun-Jing 1; Yan, Ju-Ming 2; Yang, Li-Juan 3,4; Li, Yan2 ; Zhang, Hong-Bin 1; Yang, Xiao-Dong 1
刊名	RSC ADVANCES
	2015
卷号	5 期号:78 页码:63936-63944
英文摘要	A series of novel (+/-)-3-substituted fluorene-imidazolium/triazolium salt derivatives has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of 2-methyl-benzimidazole or 5,6-dimethyl-benzimidazole rings and substitution of the imidazolyl/triazolyl3/4-position with a naphthylacyl or 4-methoxyphenacyl group were important for modulating cytotoxic activity. Compounds 37 and 42 were found to be the most potent derivatives with IC50 values of 0.51-2.51 mu M and exhibited cytotoxic activities selectively against myeloid leukaemia (HL-60), liver carcinoma (SMMC-7721) and lung carcinoma (A549). Compound 37 can remarkably induce the G2/M phase cell cycle arrest and apoptosis in SMMC-7721 cells. Additionally, compound 30 exhibited selective cytotoxicity to some extent between cancer cells (A549) and normal cells (BEAS-2B).
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	DESIGN ; CHECKPOINT ; INDUCTION ; HYBRIDS ; RING
收录类别	SCI
语种	英语
WOS记录号	WOS:000358734800096
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/25072]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Peoples R China 2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650204, Peoples R China 3.Yunnan Minzu Univ, Key Lab Ethn Med Resource Chem, State Ethn Affairs Commiss, Kunming 650500, Peoples R China 4.Yunnan Minzu Univ, Minist Educ, Kunming 650500, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jin-Mei,Wang, Min,Zhou, Yun-Jing,et al. Novel 3-substituted fluorine imidazolium/triazolium salt derivatives: synthesis and antitumor activity[J]. RSC ADVANCES,2015,5(78):63936-63944.
APA	Liu, Jin-Mei.,Wang, Min.,Zhou, Yun-Jing.,Yan, Ju-Ming.,Yang, Li-Juan.,...&Yang, Xiao-Dong.(2015).Novel 3-substituted fluorine imidazolium/triazolium salt derivatives: synthesis and antitumor activity.RSC ADVANCES,5(78),63936-63944.
MLA	Liu, Jin-Mei,et al."Novel 3-substituted fluorine imidazolium/triazolium salt derivatives: synthesis and antitumor activity".RSC ADVANCES 5.78(2015):63936-63944.