Altered resting-state functional connectivity of the amygdala in Chinese earthquake survivors | |
Zhang, Xiaoyu1,2![]() ![]() ![]() ![]() ![]() | |
刊名 | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
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2016-02-04 | |
卷号 | 65期号:0页码:208-214 |
关键词 | PTSD DSM-5 Resting-state functional connectivity Amygdala Medial prefrontal cortex |
ISSN号 | 0278-5846 |
英文摘要 | Posttraumatic stress disorder (PTSD) is linked to abnormal amygdala activities. This study measured amygdala functional connectivity using DSM-5 criteria. There were 33 participants in the PTSD group and 33 participants in a trauma-exposed control (TEC) group, who did not have PTSD according to the PTSD checklist of the DSM-5 (PCL-5). Our findings are as follows: (1) In the PTSD group, the amygdala had increased positive connectivity with the medial prefrontal cortex (mPFC) and hippocampus, and decreased positive connectivity with the inferior mPFC and insula. The amygdala had increased negative connectivity with the orbital prefrontal cortex and decreased negative connectivity with the insula in comparison with TEC group. (2) PCL of all participants was correlated with the connectivity between the amygdala and the mPFC, hippocampus, and insula. These regions overlapped with those identified in the between-group comparisons. However, there was no association between PCL of the PTSD group and connectivity in these regions. Abnormal functional connectivity between the amygdala and mPFC subdivisions, hippocampus, and insula reveals their importance in PTSD pathogenesis. (C) 2015 Elsevier Inc. All rights reserved. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
研究领域[WOS] | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
关键词[WOS] | POSTTRAUMATIC-STRESS-DISORDER ; PREFRONTAL CORTEX ; NEUROCIRCUITRY MODELS ; FMRI ; FLUCTUATIONS ; TOMOGRAPHY ; COGNITION ; SYMPTOMS ; INSIGHTS ; EMOTION |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000366709200024 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/15441] ![]() |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.UCAS, Beijing 101408, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Xiaoyu,Zhang, Jianxin,Wang, Li,et al. Altered resting-state functional connectivity of the amygdala in Chinese earthquake survivors[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2016,65(0):208-214. |
APA | Zhang, Xiaoyu,Zhang, Jianxin,Wang, Li,Li, Rui,&Zhang, Wencai.(2016).Altered resting-state functional connectivity of the amygdala in Chinese earthquake survivors.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,65(0),208-214. |
MLA | Zhang, Xiaoyu,et al."Altered resting-state functional connectivity of the amygdala in Chinese earthquake survivors".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 65.0(2016):208-214. |
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