Was it a pain or a sound? Across-species variability in sensory sensitivity | |
Hu, Li1,2,3,4; Xia, Xiaolei L.1,2; Peng, Weiwei W.1,2; Su, Wenxin X.1,2; Luo, Fei4; Yuan, Hong1,2; Chen, Antao T.1,2; Liang, Meng3; Iannetti, Giandomenico3 | |
刊名 | PAIN |
2015-12-01 | |
卷号 | 156期号:12页码:2449-2457 |
关键词 | Sensory sensitivity A delta-fibres C-fibres Electroencephalogram (EEG) Rats Humans |
ISSN号 | 0304-3959 |
英文摘要 | Natural selection has shaped the physiological properties of sensory systems across species, yielding large variations in their sensitivity. Here, we used laser stimulation of skin nociceptors, a widely used technique to investigate pain in rats and humans, to provide a vivid example of how ignoring these variations can lead to serious misconceptions in sensory neuroscience. In 6 experiments, we characterized and compared the physiological properties of the electrocortical responses elicited by laser stimulation in rats and humans. We recorded the electroencephalogram from the surface of the brain in freely moving rats and from the scalp in healthy humans. Laser stimuli elicited 2 temporally distinct responses, traditionally interpreted as reflecting the concomitant activation of different populations of nociceptors with different conduction velocities: small-myelinated Ad-fibres and unmyelinated C-fibres. Our results show that this interpretation is valid in humans, but not in rats. Indeed, the early response recorded in rats does not reflect the activation of the somatosensory system, but of the auditory system by laser-generated ultrasounds. These results have wide implications: retrospectively, as they prompt for a reconsideration of a large number of previous interpretations of electrocortical rat recordings in basic, preclinical, and pharmacological research, and prospectively, as they will allow recording truly pain-related cortical responses in rats. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Anesthesiology ; Clinical Neurology ; Neurosciences |
研究领域[WOS] | Anesthesiology ; Neurosciences & Neurology |
关键词[WOS] | PRIMARY SOMATOSENSORY CORTEX ; LASER-EVOKED-POTENTIALS ; FIELD POTENTIALS ; CO2-LASER STIMULATION ; INFRARED-LASER ; A-DELTA ; STIMULUS SALIENCY ; BRAIN POTENTIALS ; CONSCIOUS RATS ; HEAT STIMULI |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000365598300010 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/15361] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
作者单位 | 1.Southwest Univ, Key Lab Cognit & Personal, Minist Educ, Chongqing 400715, Peoples R China 2.Southwest Univ, Fac Psychol, Chongqing 400715, Peoples R China 3.UCL, Dept Neurosci Physiol & Pharmacol, London, England 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Hu, Li,Xia, Xiaolei L.,Peng, Weiwei W.,et al. Was it a pain or a sound? Across-species variability in sensory sensitivity[J]. PAIN,2015,156(12):2449-2457. |
APA | Hu, Li.,Xia, Xiaolei L..,Peng, Weiwei W..,Su, Wenxin X..,Luo, Fei.,...&Iannetti, Giandomenico.(2015).Was it a pain or a sound? Across-species variability in sensory sensitivity.PAIN,156(12),2449-2457. |
MLA | Hu, Li,et al."Was it a pain or a sound? Across-species variability in sensory sensitivity".PAIN 156.12(2015):2449-2457. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论