Chitosan-decorated calcium hydroxide microcapsules with pH-triggered release for endodontic applications

	Chitosan-decorated calcium hydroxide microcapsules with pH-triggered release for endodontic applications
	Li, Xiaoman 1; Han, Bing 1; Wang, Xiaoyan 1; Gao, Xuejun 1; Liang, Fuxin 2; Qu, Xiaozhong 3; Yang, Zhenzhong
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2015
卷号	3 期号:45 页码:8884-8891
英文摘要	The treatment of apical periodontitis (AP) remains challenging because traditional root canal therapy (RCT) outcomes are limited by the complexity of the root canal system, drug toxicity, and host immune factors. It is necessary to develop methods to prepare controlled drug release vehicles with improved biocompatibility for treatment of AP. Herein, calcium hydroxide microcapsules with chitosan and ethylcellulose coated (CS-EC@Ca(OH)(2) microcapsules) were prepared and the presence of hydrogen bonding between shell materials was observed by FT-IR. Through release assessment and biological assays, we showed that the microcapsules had enhanced controlled-release performance and biocompatibility. In particular, drug release from the microcapsules was pH-triggered. The cumulative release of drugs in pH 5.0 buffer was 8-fold higher than that in pH 7.0 buffer. Furthermore, the microcapsules exhibited prolonged antibacterial activity against refractory strains of Enterococcus faecalis. Additionally, the CS-EC@Ca(OH)(2) microcapsules reduced inflammation and promoted osteogenesis, which could be beneficial for the healing of AP with bone defects. Therefore, CS-EC@Ca(OH)(2) microcapsules improve the innate properties of Ca(OH)(2) and hold potential for AP treatment.
收录类别	SCI
语种	英语
公开日期	2015-12-29
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/29300]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Peking Univ Sch & Hosp Stomatol, Dept Cariol & Endodontol, Beijing 100081, Peoples R China 2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Xiaoman,Han, Bing,Wang, Xiaoyan,et al. Chitosan-decorated calcium hydroxide microcapsules with pH-triggered release for endodontic applications[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(45):8884-8891.
APA	Li, Xiaoman.,Han, Bing.,Wang, Xiaoyan.,Gao, Xuejun.,Liang, Fuxin.,...&Yang, Zhenzhong.(2015).Chitosan-decorated calcium hydroxide microcapsules with pH-triggered release for endodontic applications.JOURNAL OF MATERIALS CHEMISTRY B,3(45),8884-8891.
MLA	Li, Xiaoman,et al."Chitosan-decorated calcium hydroxide microcapsules with pH-triggered release for endodontic applications".JOURNAL OF MATERIALS CHEMISTRY B 3.45(2015):8884-8891.