Effective Two-Photon Excited Photodynamic Therapy of Xenograft Tumors Sensitized by Water-Soluble Bis(arylidene)cycloalkanone Photosensitizers

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	Effective Two-Photon Excited Photodynamic Therapy of Xenograft Tumors Sensitized by Water-Soluble Bis(arylidene)cycloalkanone Photosensitizers
	Zou, Qianli 1,4; Zhao, Hongyou 2; Zhao, Yuxia 1; Fang, Yanyan 1,3; Chen, Defu 2; Ren, Jie 2; Wang, Xiaopu 1,3; Wang, Ying 2; Gu, Ying 2; Wu, Feipeng 1
刊名	JOURNAL OF MEDICINAL CHEMISTRY
	2015-10-22
卷号	58 期号:20 页码:7949-7958
ISSN号	0022-2623
英文摘要	A series of bis(arylidene)cydoalkanone photo-sensitizers modified by polyethylene glycol (PEG) have been studied for two-photon excited photodynamic therapy (2PE-PDT). As compared with their prototype compounds, these PEGylated photosensitizers show enhanced water solubilities while their photophysical and photochemical properties, including linear absorption, two-photon absorption, fluorescence, and singlet oxygen quantum yield, remain unaltered. In vitro behaviors (cellular uptake, subcellular localization, photocytotomicity in both PDT and 2PE-PDT) of these photosensitizers reveal that an optimized lipid-water partition coefficient can be obtained by adjusting the length and position of the PEG chains. Among them, the photosensitizer modified asymmetrically by two tetraethylene glycol chains presents the best performance as a 2PE-PDT candidate. Selective blood-vessel closure and obvious therapeutic effect in inhibiting the growth of tumors are confirmed by in vivo 2PE-PDT after intravenous injection of this photosensitiezer. The survival periods of treated tumor-bearing mice are significantly prolonged. This study demonstrates the feasibility of using a simple molecule to construct a potential candidate for 2PE-PDT.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Chemistry, Medicinal
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	SINGLET OXYGEN ; BIOLOGICAL EVALUATION ; SILICA NANOPARTICLES ; EXCITATION ; ABSORPTION ; DESIGN ; CANCER ; CELLS ; DYES ; STANDARDS
收录类别	SCI
语种	英语
WOS记录号	WOS:000363915600006
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/19759]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, Beijing 100853, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zou, Qianli,Zhao, Hongyou,Zhao, Yuxia,et al. Effective Two-Photon Excited Photodynamic Therapy of Xenograft Tumors Sensitized by Water-Soluble Bis(arylidene)cycloalkanone Photosensitizers[J]. JOURNAL OF MEDICINAL CHEMISTRY,2015,58(20):7949-7958.
APA	Zou, Qianli.,Zhao, Hongyou.,Zhao, Yuxia.,Fang, Yanyan.,Chen, Defu.,...&Wu, Feipeng.(2015).Effective Two-Photon Excited Photodynamic Therapy of Xenograft Tumors Sensitized by Water-Soluble Bis(arylidene)cycloalkanone Photosensitizers.JOURNAL OF MEDICINAL CHEMISTRY,58(20),7949-7958.
MLA	Zou, Qianli,et al."Effective Two-Photon Excited Photodynamic Therapy of Xenograft Tumors Sensitized by Water-Soluble Bis(arylidene)cycloalkanone Photosensitizers".JOURNAL OF MEDICINAL CHEMISTRY 58.20(2015):7949-7958.