Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice

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	Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice
	Hu, Bingbing 1,2; Dai, Fengying 3; Fan, Zhanming 4; Ma, Guanghui 1; Tang, Qunwei 2; Zhang, Xin 1
刊名	ADVANCED MATERIALS
	2015-10-07
卷号	27 期号:37 页码:5499-5505
ISSN号	0935-9648
英文摘要	As nanotheranostics, Congo red/Rutin-MNPs combine the abilities of diagnosis and treatment of Alzheimer's disease (AD). The biocompatible nanotheranostics system based on iron oxide magnetic nanoparticles, with ultrasmall size and excellent magnetic properties, can specifically detect amyloid plaques by magnetic resonance imaging, realize targeted delivery of AD therapeutic agents, achieve drug controlled release by H2O2 response, and prevent oxidative stress.
WOS标题词	Science & Technology ; Physical Sciences ; Technology
类目[WOS]	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]	SUPERPARAMAGNETIC IRON-OXIDE ; BLOOD-BRAIN-BARRIER ; MRI CONTRAST AGENTS ; A-BETA PLAQUES ; OXIDATIVE STRESS ; AMYLOID PLAQUES ; T-2 CONTRAST ; MOUSE-BRAIN ; NANOPARTICLES ; DELIVERY
收录类别	SCI
语种	英语
WOS记录号	WOS:000362727900005
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/19644]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Ocean Univ China, Inst Mat Sci & Engn, Qingdao 266100, Peoples R China 3.Beijing Ctr Phys & Chem Anal, Beijing 100084, Peoples R China 4.Capital Univ, Beijing Anzhen Hosp, Dept Radiol, Beijing 100029, Peoples R China
推荐引用方式 GB/T 7714	Hu, Bingbing,Dai, Fengying,Fan, Zhanming,et al. Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice[J]. ADVANCED MATERIALS,2015,27(37):5499-5505.
APA	Hu, Bingbing,Dai, Fengying,Fan, Zhanming,Ma, Guanghui,Tang, Qunwei,&Zhang, Xin.(2015).Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice.ADVANCED MATERIALS,27(37),5499-5505.
MLA	Hu, Bingbing,et al."Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice".ADVANCED MATERIALS 27.37(2015):5499-5505.