Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress | |
Yu, Xiao-Lin1; Li, Ya-Nan2; Zhang, He3; Su, Ya-Jing4; Zhou, Wei-Wei1; Zhang, Zi-Ping2; Wang, Shao-Wei1; Xu, Peng-Xin1,2; Wang, Yu-Jiong2; Liu, Rui-Tian1 | |
刊名 | FOOD & FUNCTION
![]() |
2015 | |
卷号 | 6期号:10页码:3296-3306 |
ISSN号 | 2042-6496 |
英文摘要 | Recent evidence showed that amylin deposition is not only found in the pancreas in type 2 diabetes mellitus (T2DM) patients, but also in other peripheral organs, such as kidneys, heart and brain. Circulating amylin oligomers that cross the blood-brain barrier and accumulate in the brain may be an important contributor to diabetic cerebral injury and neurodegeneration. Moreover, increasing epidemiological studies indicate that there is a significant association between T2DM and Alzheimer's disease (AD). Amylin and beta-amyloid (A beta) may share common pathophysiology and show strikingly similar neurotoxicity profiles in the brain. To explore the potential effects of rutin on AD, we here investigated the effect of rutin on amylin aggregation by thioflavin T dyeing, evaluated the effect of rutin on amylin-induced neurocytotoxicity by the MTT assay, and assessed oxidative stress, as well as the generation of nitric oxide (NO) and pro-inflammatory cytokines in neuronal cells. Our results showed that the flavonoid antioxidant rutin inhibited amylin-induced neurocytotoxicity, decreased the production of reactive oxygen species (ROS), NO, glutathione disulfide (GSSG), malondialdehyde (MDA) and pro-inflammatory cytokines TNF-alpha and IL-1 beta, attenuated mitochondrial damage and increased the GSH/GSSG ratio. These protective effects of rutin may have resulted from its ability to inhibit amylin aggregation, enhance the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and reduce inducible nitric oxide synthase (iNOS) activity. These in vitro results indicate that rutin is a promising natural product for protecting neuronal cells from amylin-induced neurotoxicity and oxidative stress, and rutin administration could be a feasible therapeutic strategy for preventing AD development and protecting the aging brain or slowing neurodegenerative processes. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Biochemistry & Molecular Biology ; Food Science & Technology |
研究领域[WOS] | Biochemistry & Molecular Biology ; Food Science & Technology |
关键词[WOS] | ISLET AMYLOID POLYPEPTIDE ; NITRIC-OXIDE PRODUCTION ; ALZHEIMERS-DISEASE ; DIABETES-MELLITUS ; A-BETA ; MITOCHONDRIAL DYSFUNCTION ; LIPID-PEROXIDATION ; TRANSGENIC MICE ; SPATIAL MEMORY ; WISTAR RATS |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000362656400012 |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/19605] ![]() |
专题 | 过程工程研究所_生化工程国家重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Ningxia Univ, Sch Life Sci, Yinchuan 750021, Peoples R China 3.Capital Med Univ, Xuanwu Hosp, Dept Pharm, Beijing 100053, Peoples R China 4.Ningxia Med Univ, Gen Hosp, Yinchuan 750004, Peoples R China |
推荐引用方式 GB/T 7714 | Yu, Xiao-Lin,Li, Ya-Nan,Zhang, He,et al. Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress[J]. FOOD & FUNCTION,2015,6(10):3296-3306. |
APA | Yu, Xiao-Lin.,Li, Ya-Nan.,Zhang, He.,Su, Ya-Jing.,Zhou, Wei-Wei.,...&Liu, Rui-Tian.(2015).Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress.FOOD & FUNCTION,6(10),3296-3306. |
MLA | Yu, Xiao-Lin,et al."Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress".FOOD & FUNCTION 6.10(2015):3296-3306. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论