Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method
	Liu, Haixiao1,2 ; Yang, Xin1,2 ; Song, Tianming 1; Bao, Chengpeng 1; Shi, Liangliang 1,2; Hu, Zhenhua1,2 ; Wang, Kun1,2 ; Tian, Jie1,2
刊名	JOURNAL OF BIOMEDICAL OPTICS
	2015-08-01
卷号	20 期号:8
关键词	Cerenkov luminescence tomography spherical harmonics approximation multispectral diffusion theory
英文摘要	Cerenkov luminescence tomography (CLT) is a promising tool that enables three-dimensional non-invasive in vivo detection of radiopharmaceuticals. Conventionally, multispectral information and diffusion theory were introduced to achieve whole-body tomographic reconstruction. However, the diffusion theory inevitably causes systematic error in blue bands of the electromagnetic spectrum due to high-tissue absorption, and CL has a blue-weighted broad spectrum. Therefore, it is challenging to improve the accuracy of CLT. The performance of the n-order simplified spherical harmonics approximation (SPn) in different spectra is evaluated, and a multispectral hybrid CLT based on the combination of different SPn models is proposed to handle the Cerenkov photon transport problem in complex media. The in vivo xenograft experiment shows that this approach can effectively improve the quality and accuracy of the reconstructed light source. We believe that the new reconstruction method will advance the development of CLT for more in vivo imaging applications. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]	Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]	Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]	MOUSE MODEL ; LIGHT ; RADIOTRACERS ; PET
收录类别	SCI
语种	英语
WOS记录号	WOS:000362516700018
公开日期	2015-12-24
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/10040]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China 2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Liu, Haixiao,Yang, Xin,Song, Tianming,et al. Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method[J]. JOURNAL OF BIOMEDICAL OPTICS,2015,20(8).
APA	Liu, Haixiao.,Yang, Xin.,Song, Tianming.,Bao, Chengpeng.,Shi, Liangliang.,...&Tian, Jie.(2015).Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method.JOURNAL OF BIOMEDICAL OPTICS,20(8).
MLA	Liu, Haixiao,et al."Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method".JOURNAL OF BIOMEDICAL OPTICS 20.8(2015).