Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder

	Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder
	Zhu, Chao-Zhe 1,2; Zang, Yu-Feng 1,2; Cao, Qing-Jiu 3; Yan, Chao-Gan 1; He, Yong 4; Jiang, Tian-Zi2 ; Sui, Man-Qiu 3; Wang, Yu-Feng 3
刊名	NEUROIMAGE
	2008-03-01
卷号	40 期号:1 页码:110-120
关键词	Fisher discriminative analysis ADHD ReHo resting state fMRI
英文摘要	In this study a resting-state fMRI based classifier, for the first time, was proposed and applied to discriminate children with attention-deficit/hyperactivity disorder (ADHD) from normal controls. On the basis of regional homogeneity (ReHo), a mapping of brain function at resting state, PCA-based Fisher discriminative analysis (PC-FDA) was trained to build a linear classifier. Permutation test was then conducted to identify the brain areas with the most significant contribution to the final discrimination. Experimental results showed a correct classification rate of 85% using a leave-one-out cross-validation. Moreover, some highly discriminative brain regions, like the prefrontal cortex and anterior cingulate cortex, well confirmed the previous findings on ADHD. Interestingly, some important but less reported regions such as the thalamus were also identified. We conclude that the classifier, using resting-state brain function as classification feature, has potential ability to improve current diagnosis and treatment evaluation of ADHD. (c) 2007 Published by Elsevier Inc.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]	DEFICIT HYPERACTIVITY DISORDER ; ANTERIOR CINGULATE CORTEX ; REGIONAL HOMOGENEITY ; PERFORMANCE METRICS ; ACTIVATION PATTERNS ; ALZHEIMERS-DISEASE ; CONNECTIVITY ; MRI ; CLASSIFICATION ; CHILDREN
收录类别	SCI
语种	英语
WOS记录号	WOS:000253362100012
公开日期	2015-12-24
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/9674]
专题	自动化研究所_09年以前成果
作者单位	1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100875, Peoples R China 3.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China 4.McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging, Montreal, PQ H3A 2B4, Canada
推荐引用方式 GB/T 7714	Zhu, Chao-Zhe,Zang, Yu-Feng,Cao, Qing-Jiu,et al. Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder[J]. NEUROIMAGE,2008,40(1):110-120.
APA	Zhu, Chao-Zhe.,Zang, Yu-Feng.,Cao, Qing-Jiu.,Yan, Chao-Gan.,He, Yong.,...&Wang, Yu-Feng.(2008).Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder.NEUROIMAGE,40(1),110-120.
MLA	Zhu, Chao-Zhe,et al."Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder".NEUROIMAGE 40.1(2008):110-120.