Regional coherence changes in the early stages of Alzheimer's disease: A combined structural and resting-state functional MRI study

	Regional coherence changes in the early stages of Alzheimer's disease: A combined structural and resting-state functional MRI study
	He, Yong ; Wang, Liang ; Zang, Yufeng ; Tian, Lixia ; Zhang, Xinqing ; Li, Kuncheng ; Jiang, Tianzi
刊名	NEUROIMAGE
	2007-04-01
卷号	35 期号:2 页码:488-500
关键词	Alzheimer's disease default mode functional connectivity morphometry neuroimaging posterior cingulate cortex resting state spectrum
英文摘要	Recent functional imaging studies have indicated that the pathophysiology of Alzheimer's disease (AD) can be associated with the changes in spontaneous low-frequency (< 0.08 Hz) blood oxygenation level-dependent fluctuations (LFBF) measured during a resting state. The purpose of this study was to examine regional LFBF coherence patterns in early AD and the impact of regional brain atrophy on the functional results. Both structural MRI and resting-state functional MRI scans were collected from 14 AD subjects and 14 age-matched normal controls. We found significant regional coherence decreases in the posterior cingulate cortex/precuneus (PCC/PCu) in the AD patients when compared with the normal controls. Moreover, the decrease in the PCC/PCu coherence was correlated with the disease progression measured by the Mini-Mental State Exam scores. The changes in LFBF in the PCC/PCu may be related to the resting hypometabolism in this region commonly detected in previous positron emission tomography studies of early AD. When the regional PCC/ PCu atrophy was controlled, these results still remained significant but with a decrease in the statistical power, suggesting that the LFBF results are at least partly explained by the regional atrophy. In addition, we also found increased LFBF coherence in the bilateral cuneus, right lingual gyrus and left fusiform gyrus in the AD patients. These regions are consistent with previous findings of AD-related increased activation during cognitive tasks explained in terms of a compensatory- recruitment hypothesis. Finally, our study indicated that regional brain atrophy could be an important consideration in functional imaging studies of neurodegenerative diseases. (c) 2006 Elsevier Inc. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]	VOXEL-BASED MORPHOMETRY ; GRAY-MATTER LOSS ; LEVEL-DEPENDENT FLUCTUATIONS ; MILD COGNITIVE IMPAIRMENT ; MAGNETIC-RESONANCE IMAGES ; EPISODIC MEMORY RETRIEVAL ; DEFAULT-MODE ; HUMAN BRAIN ; HIPPOCAMPAL CONNECTIVITY ; CEREBRAL ATROPHY
收录类别	SCI
语种	英语
WOS记录号	WOS:000245293100005
公开日期	2015-12-24
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/9413]
专题	自动化研究所_09年以前成果
作者单位	1.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China 2.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 3.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 4.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China
推荐引用方式 GB/T 7714	He, Yong,Wang, Liang,Zang, Yufeng,et al. Regional coherence changes in the early stages of Alzheimer's disease: A combined structural and resting-state functional MRI study[J]. NEUROIMAGE,2007,35(2):488-500.
APA	He, Yong.,Wang, Liang.,Zang, Yufeng.,Tian, Lixia.,Zhang, Xinqing.,...&Jiang, Tianzi.(2007).Regional coherence changes in the early stages of Alzheimer's disease: A combined structural and resting-state functional MRI study.NEUROIMAGE,35(2),488-500.
MLA	He, Yong,et al."Regional coherence changes in the early stages of Alzheimer's disease: A combined structural and resting-state functional MRI study".NEUROIMAGE 35.2(2007):488-500.