Cytotoxic limonoids from Trichilia americana leaves

CORC > 西双版纳热带植物园 > 中国科学院西双版纳热带植物园 > 民族植物学研究组

	Cytotoxic limonoids from Trichilia americana leaves
	Hu, Hua-Bin; Xu, You-Kai
刊名	PHYTOCHEMISTRY
	2015
卷号	118 页码:61-67
关键词	Trichilia americana Meliaceae Cedrelone limonoids Cytotoxicity
ISSN号	0031-9422
中文摘要	Ten cedrelone limonoids were isolated from the leaves of Trichilia americana. These compounds include americanolides A-D (1-4), 1,2-dihydrodeacetylhirtin (5), 1 alpha-hydroxy-1,2-dihydrodeacetylhirtin (6), 1ahydroxy-1,2-dihydrohirtin (7), 1 alpha-methoxy-1,2-dihydrodeacetylhirtin (8), 11 beta-hydroxy-12 alpha-propanoyloxycedrelone (9), and 1 alpha,11 beta-dihydroxy-1,2-dihydrocedrelone (10), as well as two previously reported compounds, deacetylhirtin (11) and hirtin (12). Their structures were characterized on the basis of spectroscopic studies, and the assignment of the absolute configuration of americanolide A (1) was supported by single-crystal X-ray diffraction studies. The cytotoxic activities of all isolated compounds were also evaluated against five human tumour cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480) using an MTS assay. Compounds 11 and 12 showed significant cytotoxicity with IC50 values ranging from 0.1 to 0.5 mu M, and compounds 5, 6, 7, 8, 9, and 10 exhibited potent or selective cytotoxic activity with IC50 values ranging from 1.0 to 39.6 mu M. (C) 2015 Elsevier Ltd. All rights reserved.
资助信息	135 Programs of Xishuangbanna Tropical Botanical Garden; Chinese Academy of Sciences [XTBG-F02]; Yunnan Province; National Natural Science Union Foundation of China [NSFC-U1302222]; Ethnobotanical Investigation of Plants for Industrialization in Southwest China [SQ2012FY4910027]
原文出处	10.1016/j.phytochem.2015.08.014
语种	英语
公开日期	2015-11-19
内容类型	期刊论文
源URL	[http://ir.xtbg.org.cn/handle/353005/9350]
专题	西双版纳热带植物园_民族植物学研究组
推荐引用方式 GB/T 7714	Hu, Hua-Bin,Xu, You-Kai. Cytotoxic limonoids from Trichilia americana leaves[J]. PHYTOCHEMISTRY,2015,118:61-67.
APA	Hu, Hua-Bin,&Xu, You-Kai.(2015).Cytotoxic limonoids from Trichilia americana leaves.PHYTOCHEMISTRY,118,61-67.
MLA	Hu, Hua-Bin,et al."Cytotoxic limonoids from Trichilia americana leaves".PHYTOCHEMISTRY 118(2015):61-67.