A MoS2-based system for efficient immobilization of hemoglobin and biosensing applications

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	A MoS2-based system for efficient immobilization of hemoglobin and biosensing applications
	Chao, J; Zou, M; Zhang, C; Sun, HF; Pan, D; Pei, H; Su, S; Yuwen, LH; Fan, CH; Wang, LH
刊名	NANOTECHNOLOGY
	2015
卷号	26 期号:27 页码:—
关键词	MOLYBDENUM-DISULFIDE NANOSHEETS DIRECT ELECTRON-TRANSFER GLASSY-CARBON ELECTRODE SINGLE-LAYER MOS2 HYDROGEN-PEROXIDE NITRIC-OXIDE DIRECT ELECTROCHEMISTRY HORSERADISH-PEROXIDASE CATALYTIC-ACTIVITY AU NANOPARTICLES
英文摘要	A novel hydrogen peroxide (H2O2) and nitric oxide (NO) biosensor was fabricated by immobilizing hemoglobin (Hb) on a gold nanoparticle-decorated MoS2 nanosheet (AuNPs@MoS2) nanocomposite film modified glass carbon electrode. The AuNPs@MoS2 nanocomposite not only made the immobilized Hb keep its native biological activity but also facilitated the electron transfer between electrode and the electroactive center of Hb due to its excellent conductivity and biocompatibility. The direct electrochemistry and bioelectrocatalytic activity of Hb were investigated by cyclic voltammetry (CV). The modified electrode showed good electrocatalytic ability toward the reduction of H2O2 and NO. Under optimal conditions, the current response was linear with the concentration of H2O2 and NO in the range from 10 to 300 mu M and 10 to 1100 mu M with a detection limit of 4 and 5 mu M, respectively. This MoS2-based biosensor was sensitive, reproducible and stable, indicating that AuNPs@MoS2 nanocomposite maybe a promising platform to construct electrochemical sensors for chemical and biological molecules detection.
收录类别	SCI
语种	英语
公开日期	2015-12-24
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/24373]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Chao, J,Zou, M,Zhang, C,et al. A MoS2-based system for efficient immobilization of hemoglobin and biosensing applications[J]. NANOTECHNOLOGY,2015,26(27):—.
APA	Chao, J.,Zou, M.,Zhang, C.,Sun, HF.,Pan, D.,...&Wang, LH.(2015).A MoS2-based system for efficient immobilization of hemoglobin and biosensing applications.NANOTECHNOLOGY,26(27),—.
MLA	Chao, J,et al."A MoS2-based system for efficient immobilization of hemoglobin and biosensing applications".NANOTECHNOLOGY 26.27(2015):—.