Effects of Chinese domestic polychlorinated biphenyls (PCBs) on gonadal differentiation in Xenopus laevis

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Effects of Chinese domestic polychlorinated biphenyls (PCBs) on gonadal differentiation in Xenopus laevis
	Qin, ZF; Zhou, JM; Chu, SG; Xu, XB
刊名	ENVIRONMENTAL HEALTH PERSPECTIVES
	2003
卷号	111 期号:4 页码:553-556
关键词	endocrine disruptor gonadal differentiation ovotestis PCB3 PCB5 polychlorinated biphenyls Xenopus laevis
英文摘要	To determine whether polychlorinated biphenyls (PCBs) influence gonadal differentiation in Xenopus laevis, tadpoles were exposed to two Chinese domestic PCBs (PCB3 and PCB5) from Nieuwkoop and Faber stage 46/47 to complete metamorphosis. Gonads were characterized using a dissecting microscope. The control X laevis had normal ovaries or testes in gross morphology, whereas obviously abnormal testes including ovotestes were found in PCB3- and PCB5-exposed groups. Ovotestes were characterized by morphologic ovaries in the cranial and caudal parts and morphologic testes in the middle part. PCBs did not alter the percentage of females but reduced the percentage of males with morphologically normal testes. The histologic structure of gonads was examined by a series of sections. Morphologically normal and abnormal testes from a few frogs exposed to PCBs were interspersed with oocytes in histologic sections. These testes exhibited looser structure with fewer seminiferous tubes, spermatogonia, and spermatozoa than in controls. The findings suggest that PCB3 and PCB5 have significant feminization effects on gonadal differentiation in X laevis and that this species is sensitive to endocrine disruption and may be used as a good model to study endocrine disruption.
研究领域[WOS]	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
WOS记录号	WOS:000182144300046
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/23682]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Qin, ZF,Zhou, JM,Chu, SG,et al. Effects of Chinese domestic polychlorinated biphenyls (PCBs) on gonadal differentiation in Xenopus laevis[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2003,111(4):553-556.
APA	Qin, ZF,Zhou, JM,Chu, SG,&Xu, XB.(2003).Effects of Chinese domestic polychlorinated biphenyls (PCBs) on gonadal differentiation in Xenopus laevis.ENVIRONMENTAL HEALTH PERSPECTIVES,111(4),553-556.
MLA	Qin, ZF,et al."Effects of Chinese domestic polychlorinated biphenyls (PCBs) on gonadal differentiation in Xenopus laevis".ENVIRONMENTAL HEALTH PERSPECTIVES 111.4(2003):553-556.