Synthesis and antitumor activities of glucan derivatives

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Synthesis and antitumor activities of glucan derivatives
	Du, YG; Gu, GF; Hua, YX; Wei, GH; Ye, XS; Yu, GL
刊名	TETRAHEDRON
	2004
卷号	60 期号:30 页码:6345-6351
关键词	carbohydrates glycosylations antitumor agents glycodendrimers oligosaccharides
英文摘要	A highly efficient and practical method for the preparation of beta-D-Glc-(1-->6)-[beta-D-Glc-(1-->3)]-beta-D-Glc-(1-->6)-beta-D-Glc-(1-->6)-[beta-D-Glc-(1-->3)]-D-Glc-OMe was described. A dendritic nonasaccharide was also synthesized. The antitumor activities of hexasaccharide, the dendrimer, their sulfated derivatives, together with the natural glucan-protein and the corresponding polysaccharide isolated from barmy mycelium of Grifola frondosa, were preliminarily investigated based on Sarcoma-180 studies in mice tests. Our results suggest that the sulfated branching oligosaccharide and natural glycoprotein have better antitumor activities comparing to the parent sugar residue (oligosaccharide or polysaccharide). (C) 2004 Elsevier Ltd. All rights reserved.
研究领域[WOS]	Chemistry
WOS记录号	WOS:000222712400009
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/23485]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Du, YG,Gu, GF,Hua, YX,et al. Synthesis and antitumor activities of glucan derivatives[J]. TETRAHEDRON,2004,60(30):6345-6351.
APA	Du, YG,Gu, GF,Hua, YX,Wei, GH,Ye, XS,&Yu, GL.(2004).Synthesis and antitumor activities of glucan derivatives.TETRAHEDRON,60(30),6345-6351.
MLA	Du, YG,et al."Synthesis and antitumor activities of glucan derivatives".TETRAHEDRON 60.30(2004):6345-6351.