Synthesis and antitumor activities of glucan derivatives | |
Du, YG; Gu, GF; Hua, YX; Wei, GH; Ye, XS; Yu, GL | |
刊名 | TETRAHEDRON
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2004 | |
卷号 | 60期号:30页码:6345-6351 |
关键词 | carbohydrates glycosylations antitumor agents glycodendrimers oligosaccharides |
英文摘要 | A highly efficient and practical method for the preparation of beta-D-Glc-(1-->6)-[beta-D-Glc-(1-->3)]-beta-D-Glc-(1-->6)-beta-D-Glc-(1-->6)-[beta-D-Glc-(1-->3)]-D-Glc-OMe was described. A dendritic nonasaccharide was also synthesized. The antitumor activities of hexasaccharide, the dendrimer, their sulfated derivatives, together with the natural glucan-protein and the corresponding polysaccharide isolated from barmy mycelium of Grifola frondosa, were preliminarily investigated based on Sarcoma-180 studies in mice tests. Our results suggest that the sulfated branching oligosaccharide and natural glycoprotein have better antitumor activities comparing to the parent sugar residue (oligosaccharide or polysaccharide). (C) 2004 Elsevier Ltd. All rights reserved. |
研究领域[WOS] | Chemistry |
WOS记录号 | WOS:000222712400009 |
内容类型 | 期刊论文 |
源URL | [http://ir.rcees.ac.cn/handle/311016/23485] ![]() |
专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
推荐引用方式 GB/T 7714 | Du, YG,Gu, GF,Hua, YX,et al. Synthesis and antitumor activities of glucan derivatives[J]. TETRAHEDRON,2004,60(30):6345-6351. |
APA | Du, YG,Gu, GF,Hua, YX,Wei, GH,Ye, XS,&Yu, GL.(2004).Synthesis and antitumor activities of glucan derivatives.TETRAHEDRON,60(30),6345-6351. |
MLA | Du, YG,et al."Synthesis and antitumor activities of glucan derivatives".TETRAHEDRON 60.30(2004):6345-6351. |
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