Lignans from the Fruits of Melia toosendan and Their Agonistic Activities on Melatonin Receptor MT1

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Lignans from the Fruits of Melia toosendan and Their Agonistic Activities on Melatonin Receptor MT1
	Wang, Hao1,2 ; Geng, Chang-An1 ; Xu, Hong-Bo 1,2; Huang, Xiao-Yan 1; Ma, Yun-Bao 1; Yang, Cai-Yan 1,2; Zhang, Xue-Mei1 ; Chen, Ji-Jun1
刊名	PLANTA MEDICA
	2015-07-01
卷号	81 期号:10 页码:847-854
关键词	Melia toosendan Meliaceae lignans MT1 receptor agonistic activity
英文摘要	Investigation on the fruits of Melia toosendan afforded seven new lignans (1-7), along with seventeen known compounds (8-24). The structures of the new compounds, involving four neo-lignans (1-4), two sesquilignans (5-6), and a norlignan (7), were elucidated based on extensive spectroscopic analyses (high-resolution electrospray ionization mass spectra, ultraviolet, infrared, one-dimensional and two-dimensional nuclear magnetic resonance). Compound 24 exhibited activity on melatonin receptor type 1 with an agonistic rate of 57.77% at 1.02 mM according to the assay on HEK293 cell lines in vitro.
类目[WOS]	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]	EUCOMMIA-ULMOIDES OLIV ; BIOLOGICAL-ACTIVITIES ; INDUCED NEUROTOXICITY ; CONSTITUENTS ; LIMONOIDS ; NEOLIGNANS ; EXTRACT ; LEAVES ; PLANTS ; DAMAGE
收录类别	SCI
语种	英语
WOS记录号	WOS:000357675400010
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/24989]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Hao,Geng, Chang-An,Xu, Hong-Bo,et al. Lignans from the Fruits of Melia toosendan and Their Agonistic Activities on Melatonin Receptor MT1[J]. PLANTA MEDICA,2015,81(10):847-854.
APA	Wang, Hao.,Geng, Chang-An.,Xu, Hong-Bo.,Huang, Xiao-Yan.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2015).Lignans from the Fruits of Melia toosendan and Their Agonistic Activities on Melatonin Receptor MT1.PLANTA MEDICA,81(10),847-854.
MLA	Wang, Hao,et al."Lignans from the Fruits of Melia toosendan and Their Agonistic Activities on Melatonin Receptor MT1".PLANTA MEDICA 81.10(2015):847-854.