Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng
	Gu, Cheng-Zhen; Lv, Jun-Jiang; Zhang, Xiao-Xia; Yan, Hui; Zhu, Hong-Tao; Luo, Huai-Rong; Wang, Dong; Yang, Chong-Ren; Xu, Min; Zhang, Ying-Jun
刊名	FITOTERAPIA
	2015-06-01
卷号	103 页码:97-105
关键词	Panax notoginseng Triterpenoid saponins PC12 cells
英文摘要	Nine new minor dehydrogenated and cleavaged dammarane-type triterpenoid saponins, namely notoginsenosides ST6-ST14 (1-9) were isolated from the steamed roots of Panax notoginseng, together with 14 known ones. Among them, 5-7 and 21-22 were protopanaxadiol type and the left 18 compounds, including 1-4, 8-20, and 23 were protopanaxatriol type saponins. Their structures were identified by extensive analysis of MS, 1D and 2D NMR spectra, and acidic hydrolysis. Resulted from the side chain cleavage, the new saponins 1 and 2 featured in a ketone group at C-25, and 3-5 had an aldehyde unit at C-23. The known saponins 12,16 and 18 displayed the enhancing potential of neurite outgrowth of NGF-mediated PC12 cells at a concentration of 10 mu M, while 20 exhibited acetyl cholinesterase inhibitory activity, with IC50 value of 13.97 mu M. (C) 2015 Elsevier B.V. All rights reserved.
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	MICROBIAL TRANSFORMATION ; FLOWER-BUDS ; IN-VITRO ; GINSENG ; GLYCOSIDES ; CELLS
收录类别	SCI
语种	英语
WOS记录号	WOS:000356738800011
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/24966]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Gu, Cheng-Zhen,Lv, Jun-Jiang,Zhang, Xiao-Xia,et al. Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng[J]. FITOTERAPIA,2015,103:97-105.
APA	Gu, Cheng-Zhen.,Lv, Jun-Jiang.,Zhang, Xiao-Xia.,Yan, Hui.,Zhu, Hong-Tao.,...&Zhang, Ying-Jun.(2015).Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng.FITOTERAPIA,103,97-105.
MLA	Gu, Cheng-Zhen,et al."Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng".FITOTERAPIA 103(2015):97-105.