Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear | |
Zhou, Feng-Jiao; Nian, Yin![]() ![]() ![]() | |
刊名 | ORGANIC LETTERS
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2015-06-19 | |
卷号 | 17期号:12页码:3082-3085 |
英文摘要 | T-type calcium channel (TTCC) inhibitors hold great potential for the treatment of a variety of neurological disorders. Cochlearoids A-E (1-5), five pairs of dimeric meroterpenoid enantiomers, and cochlearines A (6) and B (7), two pairs of enantiomeric hybrid metabolites, were isolated and characterized from Ganoderma cochlear. Biological evaluation found that compounds (+)-1, (-)-3, and (+/-)-6 significantly inhibited Ca(v)3.1 TTCC and showed noticeable selectivity against Ca(v)1.2, Ca(v)2.1, Ca(v)2.2, and K(v)11.1 (hERG) channels. |
类目[WOS] | Chemistry, Organic |
研究领域[WOS] | Chemistry |
关键词[WOS] | LUCIDUM |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000356845000056 |
内容类型 | 期刊论文 |
源URL | [http://ir.kib.ac.cn/handle/151853/24965] ![]() |
专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
推荐引用方式 GB/T 7714 | Zhou, Feng-Jiao,Nian, Yin,Yan, Yongming,et al. Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear[J]. ORGANIC LETTERS,2015,17(12):3082-3085. |
APA | Zhou, Feng-Jiao.,Nian, Yin.,Yan, Yongming.,Gong, Ye.,Luo, Qj.,...&Cheng, Yong-Xian.(2015).Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear.ORGANIC LETTERS,17(12),3082-3085. |
MLA | Zhou, Feng-Jiao,et al."Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear".ORGANIC LETTERS 17.12(2015):3082-3085. |
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