Anti-inflammatory effects of 4-arylcoumarins in LPS-induced murine macrophage RAW 264.7 cells | |
Taechowisan, Thongchai; Lu, Chunhua; Shen, Yuemao; Lumyong, Saisamorn | |
刊名 | PHARMACEUTICAL BIOLOGY |
2006-11-01 | |
卷号 | 44期号:8页码:576-580 |
关键词 | 4-arylcoumarins anti-inflammatory activity endophytic Streptomyces murine macrophage RAW 264.7 cells |
英文摘要 | This research was undertaken to find the in vitro inflammatory action of 5,7-dimethyloxy-4-p-methoxyl-phenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin produced by Streptomyces aureofaciens CMUAc130. We investigated the effects of 5,7-dimethyloxy-4-p-methoxyl-phenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin not only on the formation of NO, prostaglandin E-2 (PGE(2)), and tumor necrosis factor-alpha (TNF-alpha) but also on inducible nitric oxide synthase and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells. The data obtained were consistent with the modulation of iNOS enzyme expression. A similar fashion was also observed when LPS-induced PGE(2) release and COX-2 expression were tested. The significant inhibitory effects were shown in concentration-dependent manners. In addition, 5,7dimethyloxy-4-p-methoxylphenylcoumarin and 5,7dimethoxy-4-phenylcoumarin also mildly but significantly reduced the formation of TNF-alpha. These findings support the application of 5,7-dimethyloxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin as anti-inflammatory agents. |
类目[WOS] | Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy |
研究领域[WOS] | Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy |
关键词[WOS] | HUMAN-LEUKOCYTE ELASTASE ; ANTIFUNGAL ACTIVITY ; INFLAMMATION ; DERIVATIVES ; INHIBITORS ; LIPOPOLYSACCHARIDE ; CYCLOOXYGENASE-2 ; CYTOKINES ; COUMARINS ; ACID |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000241854400003 |
公开日期 | 2015-12-24 |
内容类型 | 期刊论文 |
源URL | [http://ir.kib.ac.cn/handle/151853/24805] |
专题 | 昆明植物研究所_离退休 |
作者单位 | 1.Silpakorn Univ, Fac Sci, Dept Microbiol, Pathom 73000, Thailand 2.Xiamen Univ, Sch Life Sci, Xiamen 361005, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Kunming, Peoples R China 4.Chiang Mai Univ, Fac Sci, Dept Biol, Chiang Mai 50000, Thailand |
推荐引用方式 GB/T 7714 | Taechowisan, Thongchai,Lu, Chunhua,Shen, Yuemao,et al. Anti-inflammatory effects of 4-arylcoumarins in LPS-induced murine macrophage RAW 264.7 cells[J]. PHARMACEUTICAL BIOLOGY,2006,44(8):576-580. |
APA | Taechowisan, Thongchai,Lu, Chunhua,Shen, Yuemao,&Lumyong, Saisamorn.(2006).Anti-inflammatory effects of 4-arylcoumarins in LPS-induced murine macrophage RAW 264.7 cells.PHARMACEUTICAL BIOLOGY,44(8),576-580. |
MLA | Taechowisan, Thongchai,et al."Anti-inflammatory effects of 4-arylcoumarins in LPS-induced murine macrophage RAW 264.7 cells".PHARMACEUTICAL BIOLOGY 44.8(2006):576-580. |
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